2,4,4-Trimethylpentan-2-yl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2,4,4-Trimethylpentan-2-yl dihydrogen phosphate
• 英文别名: 2,4,4-trimethylpentan-2-yl dihydrogen phosphate
• 化学式: C₈H₁₉O₄P
• 分子量: 210.21
• InChiKey: PODBBEVXGVWXAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SEPARATION MATERIAL COMPRISING PHOSPHORYL CHOLINE DERIVATIVES
  申请人：Pentracor GmbH

  公开号：US20170120163A1

  公开（公告）日：2017-05-04

  The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: —SH, —NHR 3 , —C═CH, —CH═CH 2 , —N 3 and —CHO; the other variables are as defined in the claims: Formula (II), wherein variable “A” represents a solid support. “A” as well as the other variables are defined in detail in the claims.
• [EN] OLIGONUCLEOTIDES COMPRISING TRIAZOLE AND (PHOSPHOR)AMIDATE INTERNUCLEOSIDE LINKAGES, METHOD FOR THE PREPARATION AND USES THEREOF<br/>[FR] OLIGONUCLÉOTIDES COMPRENANT DES LIAISONS INTERNUCLÉOSIDIQUES DE TYPE TRIAZOLE ET (PHOSPHORE)AMIDATE, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：UNIV OXFORD INNOVATION LTD

  公开号：WO2019048881A1

  公开（公告）日：2019-03-14

  The present invention relates to a process for preparing oligonucleotides or oligonucleotide analogues comprising triazole and (phosphor)amidate internucleoside linkages. The present invention also relates to the oligonucleotides and oligonucleotide analogues formed from said process and to the use of these oligonucleotides and oligonucleotide analogues in the synthesis of genes, as therapeutics in treatment of certain diseases and disorders (e.g. cancer) and as templates in polymerase chain reactions, DNA replication processes, RNA transcription processes and/or translation processes.