Dimorpholino-phosphoric-acid | 6913-01-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Dimorpholino-phosphoric-acid
• 英文别名: di-morpholin-4-yl-phosphinic acid；Dimorpholin-4-ylphosphinic acid
• CAS: 6913-01-5
• 化学式: C₈H₁₇N₂O₄P
• 分子量: 236.208
• InChiKey: VWEFOEMASYDMKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NANOEMULSIONS AND USE THEREOF AS CONTRAST AGENTS
  申请人：GUERBET

  公开号：US20140234223A1

  公开（公告）日：2014-08-21

  The invention relates to an oil-in-water nanoemulsion for MRI, including: an aqueous phase, a fluorinated phase including at least one fluorinated oil, a surfactant at the interface between the aqueous and fluorinated phases, the surfactant comprising: at least one amphiphilic targeting ligand, at least one amphiphilic lipid, and at least one diblock or triblock fluorophilic compound, as well as to the use thereof as a contrast agent.

  这项发明涉及一种用于磁共振成像的油包水纳米乳液，包括： 水相， 含有至少一种氟化油的氟化相， 位于水相和氟化相之间的表面活性剂，所述表面活性剂包括： 至少一种两性靶向配体， 至少一种两性脂质，以及 至少一种二嵌段或三嵌段亲氟化合物， 以及将其用作对比剂的用途。
• Method of encapsulating a molecule and a microbead
  申请人：MEDICAL RESEARCH COUNCIL

  公开号：EP2540389A1

  公开（公告）日：2013-01-02

  The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

  本发明描述了一种合成化合物的方法，包括以下步骤(a) 将两组或两组以上的主要化合物分隔成微胶囊；使一定比例的微胶囊含有两种或两种以上的化合物；以及 (b) 通过来自不同组的主要化合物之间的化学反应，在微胶囊中形成次要化合物。本发明还可进一步鉴定与生化系统的目标成分结合或调节目标活性的化合物，并将其共同分装到微胶囊中。
• Compartmentalised combinatorial chemistry by microfluidic control
  申请人：Medical Research Council

  公开号：EP2556883A1

  公开（公告）日：2013-02-13

  The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

  本发明描述了一种合成化合物的方法，包括以下步骤(a) 将两组或两组以上的初级化合物分隔成微胶囊；使一定比例的微胶囊含有两种或两种以上的化合物；以及 (b) 通过来自不同组的初级化合物之间的化学反应在微胶囊中形成次级化合物；其中步骤(a)和步骤(b)中的一个或两个是在微流体控制下进行的；最好是电子微流体控制。本发明还可进一步鉴定与生化系统的目标成分结合或调节目标活性的化合物，并将其共同分装到微胶囊中。
• Compartmentalised screening by microfluidic control
  申请人：Medical Research Council

  公开号：EP2602018A1

  公开（公告）日：2013-06-12

  The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

  本发明描述了一种用于鉴定与生化系统的目标成分结合或调节目标活性的化合物的方法，包括以下步骤：a) 将化合物与目标成分一起分隔到微胶囊中，这样在任何一个微胶囊中都只有一个子集的化合物以多个拷贝的形式存在；b) 鉴定与目标成分结合或调节目标活性的化合物；其中至少有一个步骤是在微流体控制下进行的。本发明可以筛选出大量分子，作为药物开发的线索。
• Apparatus, system, and method using immiscible-fluid-discrete-volumes
  申请人：Life Technologies Corporation

  公开号：EP2660482A1

  公开（公告）日：2013-11-06

  A method according to an embodiment may include flowing a first fluid and a second fluid into a conduit. The first fluid and the second fluid are immiscible with respect to one another and the first fluid contains a plurality of target molecules. The maximum cross-sectional dimension of the conduit is such that a plurality of discrete volumes of the first fluid are formed in the conduit and separated from one another by the second fluid and at least one of the discrete volumes of the first fluid contains a single target molecule.

  根据一个实施方案，一种方法可包括将第一种流体和第二种流体流入导管。第一流体和第二流体彼此互不相溶，第一流体含有多个目标分子。导管的最大横截面尺寸使得多个离散的第一流体体积在导管中形成，并被第二流体彼此隔开，且至少其中一个离散的第一流体体积包含单个目标分子。