1-Adamantyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 1-Adamantyl dihydrogen phosphate
• 化学式: C₁₀H₁₇O₄P
• 分子量: 232.21
• InChiKey: QVQOTPZLFNCCIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Fused-ring compounds, pharmaceutical composition and uses thereof
  申请人：SHANGHAI DE NOVO PHARMATECH CO., LTD.

  公开号：US10202388B2

  公开（公告）日：2019-02-12

  This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.

  本公开涉及一种式(I)的熔环化合物和/或其药学上可接受的盐、一种包含式(I)的熔环化合物和/或其药学上可接受的盐的药物组合物、其制备方法以及其在调节吲哚胺2，3-二氧化酶(IDO)和/或色氨酸2，3-二氧化酶(TDO)活性中的用途。本公开进一步提供了治疗IDO和/或TDO相关疾病的方法，包括癌症、病毒感染和自身免疫性疾病。
• DETERMINATION OF NUCLEASE ACTIVITY
  申请人：Zetatronics Limited

  公开号：EP1155143A1

  公开（公告）日：2001-11-21
• FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF
  申请人：SHANGHAI DE NOVO PHARMATECH CO., LTD.

  公开号：US20180022752A1

  公开（公告）日：2018-01-25

  This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.
• [EN] DETERMINATION OF NUCLEASE ACTIVITY<br/>[FR] DETERMINATION DE L'ACTIVITE DE NUCLEASE
  申请人：HARBRON STUART

  公开号：WO2000049172A1

  公开（公告）日：2000-08-24

  A method for detecting a nuclease enzyme is disclosed which comprises a method for detecting a nuclease enzyme comprising the steps: a) contacting said enzyme with a compound of formula RpX, wherein R is a 3' nucleosidyl derivative, p is a phospho radical, and X is an esterifiable moiety or, only if R is a 3' nicotinamide derivative, X is an esterifiable moiety or H, whereby ROH and pX are produced, and b) detecting said pX moiety or, only if R is a 3' nicotinamide derivative, detecting the pX moiety or the ROH moiety. In preferred embodiments the invention provides a method for detecting a nuclease enzyme that is free in solution, immobilised on a surface, or attached to a member of a specific binding pair. The method of the invention may thus be applied as a detection step in nucleic acid hybridisation assays, enzyme immunoassays and ligand:receptor binding assays. The invention provides a variety of methods for detecting the detectable moieties produced. These include fluorometric, colorimetric, and luminometric endpoints. Enzyme cycling and apoenzyme reactivation assays are also provided.
• [EN] FUNCTIONAL GROUP IMPRINTED POLYMERS<br/>[FR] POLYMÈRES IMPRIMÉS À GROUPES FONCTIONNELS
  申请人：IMP INNOVATIONS LTD

  公开号：WO2008139204A2

  公开（公告）日：2008-11-20

  [EN] The present invention relates to a novel class of imprinted polymers, termed "functional group imprinted polymers" (FIPs), which selectively recognise molecules due to the presence of one or several predetemined funtional groups, irrespective of the type, class, substructure or size of the molecule.
  [FR] La présente invention porte sur une nouvelle classe de polymères imprimés, appelés = polymères imprimés à groupes fonctionnels = (FIP), qui reconnaît sélectivement des molécules en raison de la présence d'un ou plusieurs groupes fonctionnels prédéterminés, indépendamment du type, de la classe, de la sous-structure ou de la dimension de la molécule.