2,5-dihydrobenzo-1,6-dioxocin | 65041-54-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奥昔康唑
• 英文名称: 2,5-dihydrobenzo-1,6-dioxocin
• 英文别名: 2,5-dihydro-1,6-benzodioxocine
• CAS: 65041-54-5
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: RHTHKWDIUXNPBX-UHFFFAOYSA-N

物化性质

• 沸点：
  118 °C(Press: 12 Torr)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-二(烯丙氧基)苯 在 {[3benzyl-1-(10-phenyl-9-phenanthryl)]-2-imidazolidinylidene}dichloro(o-isopropoxyphenylmethylene)ruthenium(II) 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以82%的产率得到2,5-dihydrobenzo-1,6-dioxocin
  参考文献：
  名称：

  [EN] NOVEL RUTHENIUM COMPLEX, METHOD OF ITS PRODUCTION AND ITS USE IN REACTION OF OLEFINE METATHESIS
  [FR] NOUVEAU COMPLEXE DE RUTHÉNIUM, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION DANS LA RÉACTION DE MÉTATHÈSE D'OLÉFINES

  摘要：

  该发明涉及公式（9）的新型钌配合物。该发明还涉及制备公式（9）的新金属配合物的方法以及它们在烯烃交换反应中的应用。

  公开号：

  WO2018100515A1

文献信息

• An Investigation of Wall Effects in Microwave-Assisted Ring-Closing Metathesis and Cyclotrimerization Reactions
  作者：Doris Dallinger、Muhammed Irfan、Amra Suljanovic、C. Oliver Kappe

  DOI：10.1021/jo1011703

  日期：2010.8.6

  Challenging Ru-catalyzed ring-closing metathesis transformations leading to eight-membered-ring systems and Ni- or Co-catalyzed [2+2+2] cyclotrimerizations were evaluated at elevated temperatures applying microwave dielectric heating or conventional thermal heating in order to investigate the role of wall effects. All reactions were conducted in a dedicated reactor setup that allowed accurate internal reaction temperature measurements using fiber-optic probes for both types of heating modes. For ring-closing metathesis best results were achieved using an open vessel gas sparging protocol in 1,2-dichloroethane at reflux temperature (83 degrees C), while cyclotrimerizations were performed under sealed vessel conditions in toluene between 80 and 160 degrees C. For all studied transformations the results achieved in a single-mode microwave reactor could be reproduced by conventional heating in an oil bath by carefully matching the temperature profiles as close as possible during the entire heating and cooling cycle. In contrast to previous literature reports, no evidence that direct in-core microwave heating can increase catalyst lifetime by minimization or elimination of wall effects was obtained. At the same time, no indication for the involvement of nonthermal microwave effects in these homogeneous transition metal-catalyzed transformations was seen.
• [EN] NOVEL RUTHENIUM COMPLEX, METHOD OF ITS PRODUCTION AND ITS USE IN REACTION OF OLEFINE METATHESIS<br/>[FR] NOUVEAU COMPLEXE DE RUTHÉNIUM, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION DANS LA RÉACTION DE MÉTATHÈSE D'OLÉFINES
  申请人：UNIV WARSZAWSKI

  公开号：WO2018100515A1

  公开（公告）日：2018-06-07

  The invention relates to novel ruthenium complexes of formula (9). The invention also relates to the method for preparation of novel metal complexes of formula (9) and their use in olefin metathesis reactions.

  该发明涉及公式（9）的新型钌配合物。该发明还涉及制备公式（9）的新金属配合物的方法以及它们在烯烃交换反应中的应用。