3,4,4'-tri-O-benzyl-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-2'-O-palmitoyl-α,α-D-trehalose | 1007885-96-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: 3,4,4'-tri-O-benzyl-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-2'-O-palmitoyl-α,α-D-trehalose
• 英文别名: [(2R,3R,4S,5S,6R)-6-[(3,4-dimethoxyphenyl)methoxymethyl]-2-[(2R,3R,4S,5R,6R)-6-[(3,4-dimethoxyphenyl)methoxymethyl]-3-[(4-methoxyphenyl)methoxy]-4,5-bis(phenylmethoxy)oxan-2-yl]oxy-4-hydroxy-5-phenylmethoxyoxan-3-yl] hexadecanoate
• CAS: 1007885-96-2
• 化学式: C₇₅H₉₈O₁₇
• 分子量: 1271.59
• InChiKey: BQLZZWGPXLBYMF-WCTMEGNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.7
• 重原子数：
  92
• 可旋转键数：
  43
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  176
• 氢给体数：
  1
• 氢受体数：
  17

反应信息

• 作为反应物：
  描述：

  3,4,4'-tri-O-benzyl-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-2'-O-palmitoyl-α,α-D-trehalose 、 (S)-2-methyloctadecanoic acid 在 4-二甲氨基吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到3,4,4'-tri-O-benzyl-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-3'-O-((S)-2-methylstearoyl)-2'-O-palmitoyl-α,α-D-trehalose
  参考文献：
  名称：

  Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I

  摘要：

  [GRAPHICS]Sulfolipid-I (SL-I) is an abundant metabolite found in the cell wall of Mycobacterium tuberculosis that is comprised of a trehalose 2-sulfate core modified with four fatty acyl substituents. The correlation of its abundance with the virulence of clinical isolates suggests a role for SL-I in pathogenesis, although its biological functions remain unknown. Here we describe the synthesis of a SL-I analogue bearing unnatural lipid substituents. A key feature of the synthesis was application of an intramolecular aglycon delivery reaction to join two differentially protected glucose monomers, one prepared with a novel alpha-selective glycosylation. The route developed for the model compound can be readily extended to the synthesis of native SL-I as well as additional analogues for use in the investigation of SL-I's functions.

  DOI：

  10.1021/jo702032c
• 作为产物：
  描述：

  3,4,4'-tri-O-benzyl-3'-O-(p-(N-methyl-N-phenylamino)benzyl)-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-2'-O-palmitoyl-α,α-D-trehalose 在 zinc(II) chloride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 1.0h， 以76%的产率得到3,4,4'-tri-O-benzyl-6,6'-di-O-(3,4-dimethoxybenzyl)-2-O-(p-methoxybenzyl)-2'-O-palmitoyl-α,α-D-trehalose
  参考文献：
  名称：

  Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I

  摘要：

  [GRAPHICS]Sulfolipid-I (SL-I) is an abundant metabolite found in the cell wall of Mycobacterium tuberculosis that is comprised of a trehalose 2-sulfate core modified with four fatty acyl substituents. The correlation of its abundance with the virulence of clinical isolates suggests a role for SL-I in pathogenesis, although its biological functions remain unknown. Here we describe the synthesis of a SL-I analogue bearing unnatural lipid substituents. A key feature of the synthesis was application of an intramolecular aglycon delivery reaction to join two differentially protected glucose monomers, one prepared with a novel alpha-selective glycosylation. The route developed for the model compound can be readily extended to the synthesis of native SL-I as well as additional analogues for use in the investigation of SL-I's functions.

  DOI：

  10.1021/jo702032c

文献信息

• Synthetic Studies toward <i>Mycobacterium tuberculosis</i> Sulfolipid-I
  作者：Clifton D. Leigh、Carolyn R. Bertozzi

  DOI：10.1021/jo702032c

  日期：2008.2.1

  [GRAPHICS]Sulfolipid-I (SL-I) is an abundant metabolite found in the cell wall of Mycobacterium tuberculosis that is comprised of a trehalose 2-sulfate core modified with four fatty acyl substituents. The correlation of its abundance with the virulence of clinical isolates suggests a role for SL-I in pathogenesis, although its biological functions remain unknown. Here we describe the synthesis of a SL-I analogue bearing unnatural lipid substituents. A key feature of the synthesis was application of an intramolecular aglycon delivery reaction to join two differentially protected glucose monomers, one prepared with a novel alpha-selective glycosylation. The route developed for the model compound can be readily extended to the synthesis of native SL-I as well as additional analogues for use in the investigation of SL-I's functions.