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吡唑并嘧啶类

中文名称 英文名称 CAS号 化学式 结构式图片
—— 1-methyl-5-[1-methyl-4-(4-methylpiperazin-1-yl)sulfonylpyrrol-2-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one 260780-81-2 C19H27N7O3S
1-methyl-5-[1-methyl-4-(4-methylpiperazin-1-yl)sulfonylpyrrol-2-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
—— [(3R)-3-(5-bromo-2-hydroxyphenyl)-5-(5-bromothiophen-2-yl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C25H13Br2ClF3N5O2S2
[(3R)-3-(5-bromo-2-hydroxyphenyl)-5-(5-bromothiophen-2-yl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— [(3S)-3-(5-bromo-2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C27H16BrClF3N5O2S
[(3S)-3-(5-bromo-2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— [(3S)-3-(5-bromo-2-hydroxyphenyl)-5-(5-bromothiophen-2-yl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C25H13Br2ClF3N5O2S2
[(3S)-3-(5-bromo-2-hydroxyphenyl)-5-(5-bromothiophen-2-yl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— 3-bromo-N-[(6S)-6-tert-butyl-3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide —— C25H23BrF3N5O2S2
3-bromo-N-[(6S)-6-tert-butyl-3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
—— [(3R)-3-(5-bromo-2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C27H16BrClF3N5O2S
[(3R)-3-(5-bromo-2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— propan-2-yl (6S)-2-[[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate —— C30H24ClF3N4O3S2
propan-2-yl (6S)-2-[[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
—— ethyl (6S)-2-[[3-bromo-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate —— C27H26BrF3N4O3S2
ethyl (6S)-2-[[3-bromo-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
—— (5S,7S)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide —— C32H32F3N5O4
(5S,7S)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
—— propan-2-yl (6R)-2-[[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate —— C30H24ClF3N4O3S2
propan-2-yl (6R)-2-[[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
—— ethyl (6R)-2-[[3-bromo-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate —— C27H26BrF3N4O3S2
ethyl (6R)-2-[[3-bromo-5-thiophen-2-yl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
—— [5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3S)-5-(4-fluorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]methanone —— C27H16ClF4N5O2S
[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3S)-5-(4-fluorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]methanone
—— (5S,7R)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide —— C32H32F3N5O4
(5S,7R)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
—— [5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3S)-3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone —— C28H19ClF3N5O2S
[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3S)-3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone
—— [5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone —— C28H19ClF3N5O2S
[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone
—— [(3R)-5-(2-chlorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C27H16Cl2F3N5O2S
[(3R)-5-(2-chlorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— [5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-3-(2-hydroxyphenyl)-5-(3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]methanone —— C28H19ClF3N5O3S
[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-3-(2-hydroxyphenyl)-5-(3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]methanone
—— (5R,7S)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide —— C32H32F3N5O4
(5R,7S)-N-[(Z)-[3-[(2,3-dimethylphenoxy)methyl]-4-methoxyphenyl]methylideneamino]-5-(4-methoxyphenyl)-7-(trifluoromethyl)-1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
—— [5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-5-(4-fluorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]methanone —— C27H16ClF4N5O2S
[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-[(3R)-5-(4-fluorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]methanone
—— [(3S)-5-(2-chlorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone —— C27H16Cl2F3N5O2S
[(3S)-5-(2-chlorophenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-[5-(5-chlorothiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
—— 3-(4-tert-butyl-benzenesulphonyl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidin-7-ylamine —— C18H22N4O2S2
3-(4-tert-butyl-benzenesulphonyl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidin-7-ylamine
—— 13-(difluoromethyl)-4-[(5S,7S)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene —— C25H18F4N8S
13-(difluoromethyl)-4-[(5S,7S)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene
—— 1-cyclopentyl-3-ethyl-6-(2-propoxyphenyl)-pyrazolo[3,4-d]pyrimidin-4-one —— C21H26N4O2
1-cyclopentyl-3-ethyl-6-(2-propoxyphenyl)-pyrazolo[3,4-d]pyrimidin-4-one
—— 4-butyl-2-(3-chloro-propane-1-sulfonyl)-6-methyl-2,4-dihydro-pyrazolo[4,3-d]-pyrimidine-5,7-dione —— C13H19ClN4O4S
4-butyl-2-(3-chloro-propane-1-sulfonyl)-6-methyl-2,4-dihydro-pyrazolo[4,3-d]-pyrimidine-5,7-dione
—— 13-(difluoromethyl)-4-[(5R,7R)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene —— C25H18F4N8S
13-(difluoromethyl)-4-[(5R,7R)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene
—— 13-(difluoromethyl)-4-[(5R,7S)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene —— C25H18F4N8S
13-(difluoromethyl)-4-[(5R,7S)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene
—— 13-(difluoromethyl)-4-[(5S,7R)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene —— C25H18F4N8S
13-(difluoromethyl)-4-[(5S,7R)-7-(difluoromethyl)-5-phenyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrimidin-3-ylidene]-11-methyl-16-thia-3,5,6,8,14-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,7,10(15),11,13-hexaene
—— 5-Benzyl-4,8-dimethyl-11-propan-2-yl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-one —— C19H23N5O
5-Benzyl-4,8-dimethyl-11-propan-2-yl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-one
—— 4-chloro-1-N-(3-propan-2-yl-2H-pyrazolo[4,3-d]pyrimidin-7-yl)benzene-1,3-diamine —— C14H15ClN6
4-chloro-1-N-(3-propan-2-yl-2H-pyrazolo[4,3-d]pyrimidin-7-yl)benzene-1,3-diamine
—— 2-(2,6-dichlorobenzyl)pyrazolo[3,4-d]pyrimidin-4(5H)-one —— C12H8Cl2N4O
2-(2,6-dichlorobenzyl)pyrazolo[3,4-d]pyrimidin-4(5H)-one
—— 5-(2-chloro-6-fluorobenzyl)-2-butyl-2,5-dihydropyrazolo[3,4-d]pyrimidin-4-one 402570-88-1 C16H16ClFN4O
5-(2-chloro-6-fluorobenzyl)-2-butyl-2,5-dihydropyrazolo[3,4-d]pyrimidin-4-one
—— 2-[1-(2-chlorophenyl)cyclobutyl]-5-(hydroxymethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one —— C17H16ClN3O2
2-[1-(2-chlorophenyl)cyclobutyl]-5-(hydroxymethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one
—— 6-[[[(1S)-1-(2-fluorophenyl)ethyl]-methylamino]methyl]-1-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one —— C16H18FN5O
6-[[[(1S)-1-(2-fluorophenyl)ethyl]-methylamino]methyl]-1-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
—— 5-(2-chlorobenzyl)-6-methyl-2,5-dihydropyrazolo[3,4-d]-pyrimidin-4-one 402571-03-3 C13H11ClN4O
5-(2-chlorobenzyl)-6-methyl-2,5-dihydropyrazolo[3,4-d]-pyrimidin-4-one
—— 5-(2,6-difluorobenzyl)-2,5-dihydropyrazolo[3,4-d]-pyrimidin-4-one 402570-44-9 C12H8F2N4O
5-(2,6-difluorobenzyl)-2,5-dihydropyrazolo[3,4-d]-pyrimidin-4-one
—— N-[(2R)-2-hydroxy-2-thiophen-2-ylethyl]-2,7-dimethylpyrazolo[1,5-a]pyrimidine-5-carboxamide —— C15H16N4O2S
N-[(2R)-2-hydroxy-2-thiophen-2-ylethyl]-2,7-dimethylpyrazolo[1,5-a]pyrimidine-5-carboxamide
—— N-[(2S)-2-hydroxy-2-thiophen-2-ylethyl]-2,7-dimethylpyrazolo[1,5-a]pyrimidine-5-carboxamide —— C15H16N4O2S
N-[(2S)-2-hydroxy-2-thiophen-2-ylethyl]-2,7-dimethylpyrazolo[1,5-a]pyrimidine-5-carboxamide
—— N-[2-[[(3R,5S)-3,5-dimethyl-1-adamantyl]oxy]ethyl]pyrazolo[1,5-a]pyrimidine-2-carboxamide —— C21H28N4O2
N-[2-[[(3R,5S)-3,5-dimethyl-1-adamantyl]oxy]ethyl]pyrazolo[1,5-a]pyrimidine-2-carboxamide
—— N-[(2S)-2-(hydroxymethyl)-3-thiophen-2-ylpropyl]-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide —— C16H18N4O2S
N-[(2S)-2-(hydroxymethyl)-3-thiophen-2-ylpropyl]-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
—— N-[(2R)-2-(hydroxymethyl)-3-thiophen-3-ylpropyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide —— C16H18N4O2S
N-[(2R)-2-(hydroxymethyl)-3-thiophen-3-ylpropyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
—— N-[(2S)-2-(hydroxymethyl)-3-thiophen-3-ylpropyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide —— C16H18N4O2S
N-[(2S)-2-(hydroxymethyl)-3-thiophen-3-ylpropyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
—— N-[(2S)-2-(furan-2-yl)-2-pyrrolidin-1-ylethyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide —— C18H21N5O2
N-[(2S)-2-(furan-2-yl)-2-pyrrolidin-1-ylethyl]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide
—— N-[(2R)-2-(hydroxymethyl)-3-thiophen-2-ylpropyl]-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide —— C16H18N4O2S
N-[(2R)-2-(hydroxymethyl)-3-thiophen-2-ylpropyl]-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
—— N-methyl-N-[(3-methylsulfonylpyrazolo[1,5-a]pyrimidin-6-yl)methyl]-2-[(2S)-oxan-2-yl]ethanamine —— C16H24N4O3S
N-methyl-N-[(3-methylsulfonylpyrazolo[1,5-a]pyrimidin-6-yl)methyl]-2-[(2S)-oxan-2-yl]ethanamine
—— N-methyl-N-[(3-methylsulfonylpyrazolo[1,5-a]pyrimidin-6-yl)methyl]-2-[(2R)-oxan-2-yl]ethanamine —— C16H24N4O3S
N-methyl-N-[(3-methylsulfonylpyrazolo[1,5-a]pyrimidin-6-yl)methyl]-2-[(2R)-oxan-2-yl]ethanamine
—— (7-methylpyrazolo[1,5-a]pyrimidin-6-yl)-[(3S)-3-(1-propan-2-ylimidazol-2-yl)piperidin-1-yl]methanone —— C19H24N6O
(7-methylpyrazolo[1,5-a]pyrimidin-6-yl)-[(3S)-3-(1-propan-2-ylimidazol-2-yl)piperidin-1-yl]methanone
—— (7-methylpyrazolo[1,5-a]pyrimidin-6-yl)-[(3R)-3-(1-propan-2-ylimidazol-2-yl)piperidin-1-yl]methanone —— C19H24N6O
(7-methylpyrazolo[1,5-a]pyrimidin-6-yl)-[(3R)-3-(1-propan-2-ylimidazol-2-yl)piperidin-1-yl]methanone
—— [(6S)-6-hydroxy-4-(pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-1,4-diazepan-1-yl]-(1H-pyrazol-5-yl)methanone —— C16H19N7O2
[(6S)-6-hydroxy-4-(pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-1,4-diazepan-1-yl]-(1H-pyrazol-5-yl)methanone
—— [(6R)-6-hydroxy-4-(pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-1,4-diazepan-1-yl]-(1H-pyrazol-5-yl)methanone —— C16H19N7O2
[(6R)-6-hydroxy-4-(pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-1,4-diazepan-1-yl]-(1H-pyrazol-5-yl)methanone
—— (2,7-dimethylpyrazolo[1,5-a]pyrimidin-5-yl)-[(2S)-2-(2-thiophen-2-ylethyl)piperidin-1-yl]methanone —— C20H24N4OS
(2,7-dimethylpyrazolo[1,5-a]pyrimidin-5-yl)-[(2S)-2-(2-thiophen-2-ylethyl)piperidin-1-yl]methanone