申请人:Stevenson Nigel R.
公开号:US09336916B2
公开(公告)日:2016-05-10
Methods for producing Tc-99m radioisotope by proton irradiation of a fluid target matrix. A method of producing Tc-99m includes irradiating a fluid target matrix comprising Mo-100 with a proton beam to transform at least a portion of Mo-100 to Tc-99m. Optionally, the fluid target matrix further includes at least one of O-18, O-16, or N-14, which upon exposure to the proton beam concurrently transform at least a portion of O-18 to F-18, at least a portion of O-16 to N-13, at least a portion of the O-16 to O-15, or at least a portion of N-14 to C-11. The method further includes isolating Tc-99m and optionally at least one of F-18, N-13, O-15, or C-11 from the irradiated fluid target matrix. An additional source of Tc-99m is available from the decay of Mo-99 that is co-produced from the Mo-100 during irradiation with the proton beam.
通过质子辐照液态靶基质制备Tc-99m放射性同位素的方法。制备Tc-99m的方法包括将含有Mo-100的液态靶基质用质子束照射,将Mo-100的至少一部分转化为Tc-99m。可选地,液态靶基质还包括至少一种O-18、O-16或N-14,当暴露于质子束时,同时将至少一部分O-18转化为F-18、至少一部分O-16转化为N-13、至少一部分O-16转化为O-15或至少一部分N-14转化为C-11。该方法还包括从辐照的液态靶基质中分离Tc-99m和可选的至少一种F-18、N-13、O-15或C-11。Mo-100在与质子束辐照期间共同产生的Mo-99的衰变还提供了Tc-99m的额外来源。