hydrogenase (acceptor) | 9027-05-8

• 分子结构分类: 氧化还原酶 - 以氢为供体 - 带有未知的生理受体
• 英文名称: hydrogenase (acceptor)
• 英文别名: H2 producing hydrogenase (ambiguous)；hydrogen-lyase (ambiguous)；hydrogenlyase (ambiguous)；uptake hydrogenase (ambiguous)；hydrogen:(acceptor) oxidoreductase；hydrogenase
• CAS: 9027-05-8

反应信息

• 作为试剂：
  描述：

  仲辛酮 在 D-丙氨酸 、 hydrogenase (acceptor) 、 L-alanine dehydrogenase 、 ω-transaminase from Aspergillus terreus 、 氢气 、 氯化铵 、 sodium β-nicotinamide adenine dinucleotide phosphate 作用下， 以 aq. phosphate buffer 为溶剂， 30.0 ℃ 、200.0 kPa 条件下， 反应 8.0h， 以99%的产率得到
  参考文献：
  名称：

  Asymmetric Biocatalytic Amination of Ketones at the Expense of NH₃ and Molecular Hydrogen

  摘要：

  A biocatalytic system is presented for the stereoselective amination of ketones at the expense of NH3 and molecular hydrogen. By using a NAD(+)-reducing hydrogenase, an alanine dehydrogenase, and a suitable omega-transaminase, the R- as well as the S-enantiomer of various amines could be prepared with up to >99% ee and 98% conversion.

  DOI：

  10.1021/acs.orglett.5b01154