| 1269818-23-6

• CAS: 1269818-23-6
• 化学式: C₃₅H₂₇BF₂N₂O₂
• 分子量: 556.419
• InChiKey: OVXVWCADMLTXRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  、 manganese(ll) chloride 在 2,6-lutidine 作用下， 以 甲醇 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers

  摘要：

  We report a new series of biscyclohexanofused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, 4a-c, as potent and orally active peroxynitrite scavengers. Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained BODIPY analogue 9b were analyzed by X-ray crystallography. Finally, complex 4a is shown to be an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the overproduction of peroxynitrite.

  DOI：

  10.1021/ja110427e
• 作为产物：
  描述：

  2-tert-butyl 1-ethyl 3-bromo-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate 在 四(三苯基膦)钯 、 三溴化硼 、 四氯苯醌 、 sodium carbonate 、 三氟乙酸 、 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 水 、 乙二醇 、 甲苯 为溶剂， 反应 17.67h， 生成
  参考文献：
  名称：

  Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers

  摘要：

  We report a new series of biscyclohexanofused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, 4a-c, as potent and orally active peroxynitrite scavengers. Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained BODIPY analogue 9b were analyzed by X-ray crystallography. Finally, complex 4a is shown to be an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the overproduction of peroxynitrite.

  DOI：

  10.1021/ja110427e