1-[1-(2-methoxyphenyl)-4-propylpiperazine]-closo-1,2-C2B10H11 | 1299472-31-3

• 英文名称: 1-[1-(2-methoxyphenyl)-4-propylpiperazine]-closo-1,2-C2B10H11
• CAS: 1299472-31-3
• 化学式: C₁₆H₃₂B₁₀N₂O
• 分子量: 376.553
• InChiKey: BMDUZHKKPRCRKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-[1-(2-methoxyphenyl)-4-propylpiperazine]-closo-1,2-C2B10H11 在 NaF 作用下， 以 not given 为溶剂， 生成
  参考文献：
  名称：

  The preparation and characterization of functionalized carboranes and Re/Tc-metallocarboranes as platforms for developing molecular imaging probes: Structural and cage isomerism studies

  摘要：

  A study of the structure and reactivity of a series of carborane ligands [(RC2B9H11)(-)] towards Re(I) and Tc-99m(I) was undertaken in which the arising products [(M(CO)(3)RC2B9H10)(-), M = Re, Tc-99m] can be used as platforms to develop organometallic molecular imaging agents. Synthetic methods are reported that produce good yields of the target ligands and metal complexes where the organometallic complexes were prepared in aqueous solvents at both the macroscopic scale and at the tracer level. NMR and X-ray crystallography studies confirmed the structures of the closo and nido-ligands and demonstrated that the rhenacarborane complexes exist as 3,1,2 and/or 2,1,8 isomers where the product distribution depends upon on the steric bulk and electronic influence of the substituent linked to the carbon atom of the carborane cage. Experiments at the tracer level with Tc-99m(I) demonstrated for one ligand a difference in the ratio of isomers produced and the reactivity of the ligands compared to that for Re(I). Data is also presented to show for the first time that a 3,1,2-technetium carborane forms initially during radiolabeling and then upon heating isomerizes to the more stable 2,1,8 isomer. The comparable process is not observed for rhenium. The log D values for the technetium complexes were also measured and are within the range needed to cross the blood-brain-barrier making the reported compounds viable candidates for imaging key targets in the central nervous system. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.03.017
• 作为产物：
  描述：

  1-(2-甲氧苯基)哌嗪 、 1-(3'-iodopropyl)-1,2-dicarba-closo-dodecaborane 在 diisopropylethylamine 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到1-[1-(2-methoxyphenyl)-4-propylpiperazine]-closo-1,2-C2B10H11
  参考文献：
  名称：

  The preparation and characterization of functionalized carboranes and Re/Tc-metallocarboranes as platforms for developing molecular imaging probes: Structural and cage isomerism studies

  摘要：

  A study of the structure and reactivity of a series of carborane ligands [(RC2B9H11)(-)] towards Re(I) and Tc-99m(I) was undertaken in which the arising products [(M(CO)(3)RC2B9H10)(-), M = Re, Tc-99m] can be used as platforms to develop organometallic molecular imaging agents. Synthetic methods are reported that produce good yields of the target ligands and metal complexes where the organometallic complexes were prepared in aqueous solvents at both the macroscopic scale and at the tracer level. NMR and X-ray crystallography studies confirmed the structures of the closo and nido-ligands and demonstrated that the rhenacarborane complexes exist as 3,1,2 and/or 2,1,8 isomers where the product distribution depends upon on the steric bulk and electronic influence of the substituent linked to the carbon atom of the carborane cage. Experiments at the tracer level with Tc-99m(I) demonstrated for one ligand a difference in the ratio of isomers produced and the reactivity of the ligands compared to that for Re(I). Data is also presented to show for the first time that a 3,1,2-technetium carborane forms initially during radiolabeling and then upon heating isomerizes to the more stable 2,1,8 isomer. The comparable process is not observed for rhenium. The log D values for the technetium complexes were also measured and are within the range needed to cross the blood-brain-barrier making the reported compounds viable candidates for imaging key targets in the central nervous system. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.03.017