tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucyl-D-prolinate | 1380237-43-3

• 英文名称: tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucyl-D-prolinate
• CAS: 1380237-43-3
• 化学式: C₂₇H₄₁N₃O₆
• 分子量: 503.639
• InChiKey: PGTPVCPYQIIRTP-LEWJYISDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.56
• 重原子数：
  36.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  114.04
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucyl-D-prolinate 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides

  摘要：

  Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that effect gene regulation. To know the interaction of aliphatic cap groups with HDACs, cyclic tetrapeptide and bicyclic peptide disulfide hybrids were synthesized without aromatic ring in their macrocyclic framework. Benzene ring Of L-Phe in chlamydocin was replaced with several aliphatic amino acids and also a fused bicyclic tetrapeptide was synthesized by ring closing metathesis using Grubb's first generation catalyst. The inhibitory activities of the cyclic peptides against historic deacetylase enzymes were evaluated, which demonstrated most of them are interesting candidates as anticancer agents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.09.021
• 作为产物：
  描述：

  H-L-Leu-D-Pro-OtBu 、 N-苄氧羰酰基-2-甲基丙氨酸 在 1-羟基苯并三唑一水物 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucyl-D-prolinate
  参考文献：
  名称：

  Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides

  摘要：

  Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that effect gene regulation. To know the interaction of aliphatic cap groups with HDACs, cyclic tetrapeptide and bicyclic peptide disulfide hybrids were synthesized without aromatic ring in their macrocyclic framework. Benzene ring Of L-Phe in chlamydocin was replaced with several aliphatic amino acids and also a fused bicyclic tetrapeptide was synthesized by ring closing metathesis using Grubb's first generation catalyst. The inhibitory activities of the cyclic peptides against historic deacetylase enzymes were evaluated, which demonstrated most of them are interesting candidates as anticancer agents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.09.021