3,5-bis(p-chlorophenyl)-N-hydroxymethylene-tetrahydro-1,4-thiazine-1,1-dioxide | 1031422-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 3,5-bis(p-chlorophenyl)-N-hydroxymethylene-tetrahydro-1,4-thiazine-1,1-dioxide
• 英文别名: [3,5-Bis(4-chlorophenyl)-1,1-dioxo-1,4-thiazinan-4-yl]methanol；[3,5-bis(4-chlorophenyl)-1,1-dioxo-1,4-thiazinan-4-yl]methanol
• CAS: 1031422-69-1
• 化学式: C₁₇H₁₇Cl₂NO₃S
• 分子量: 386.299
• InChiKey: XZIFWIMECSMWOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-bis(p-chlorophenyl)-N-hydroxymethylene-tetrahydro-1,4-thiazine-1,1-dioxide 、 硫酸二甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 4.0h， 以56%的产率得到3,5-bis(p-chlorophenyl)-N-methoxymethylene-tetrahydro-1,4-thiazine-1,1-dioxide
  参考文献：
  名称：

  Synthesis and biological activities of some N-hydroxymethylene and N-methoxymethylene thiazines

  摘要：

  A series of new 3,5-diaryl-N-hydroxymethylene-1,4-thiazine-1,1-dioxides and3,5-diaryl-N-methoxymethylene-tetrahydro-1,4-thiazines-1,1-dioxides were synthesized and their antimicrobial activities were tested against Gram-positive (Bacillus subtilis, Streptococci) and Gram-negative bacteria ( Escherichia coli and Klebsiella penumoniae) and against the fungi Penicillium inclobium and Aspergillus flavus. The synthesized compounds have been characterized on the basis of elemental analyses, infrared spectroscopy (IR), and nuclear magnetic resonance (NMR).

  DOI：

  10.1007/s00044-007-9059-y
• 作为产物：
  描述：

  聚合甲醛 、 3,5-双(对氯苯基)四氢-1,4-噻嗪1,1-二氧化物 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以52%的产率得到3,5-bis(p-chlorophenyl)-N-hydroxymethylene-tetrahydro-1,4-thiazine-1,1-dioxide
  参考文献：
  名称：

  Synthesis and biological activities of some N-hydroxymethylene and N-methoxymethylene thiazines

  摘要：

  A series of new 3,5-diaryl-N-hydroxymethylene-1,4-thiazine-1,1-dioxides and3,5-diaryl-N-methoxymethylene-tetrahydro-1,4-thiazines-1,1-dioxides were synthesized and their antimicrobial activities were tested against Gram-positive (Bacillus subtilis, Streptococci) and Gram-negative bacteria ( Escherichia coli and Klebsiella penumoniae) and against the fungi Penicillium inclobium and Aspergillus flavus. The synthesized compounds have been characterized on the basis of elemental analyses, infrared spectroscopy (IR), and nuclear magnetic resonance (NMR).

  DOI：

  10.1007/s00044-007-9059-y

文献信息

• Synthesis and biological activities of some N-hydroxymethylene and N-methoxymethylene thiazines
  作者：V. Sundari、G. Nagarajan、R. Valliappan

  DOI：10.1007/s00044-007-9059-y

  日期：2007.12

  A series of new 3,5-diaryl-N-hydroxymethylene-1,4-thiazine-1,1-dioxides and3,5-diaryl-N-methoxymethylene-tetrahydro-1,4-thiazines-1,1-dioxides were synthesized and their antimicrobial activities were tested against Gram-positive (Bacillus subtilis, Streptococci) and Gram-negative bacteria ( Escherichia coli and Klebsiella penumoniae) and against the fungi Penicillium inclobium and Aspergillus flavus. The synthesized compounds have been characterized on the basis of elemental analyses, infrared spectroscopy (IR), and nuclear magnetic resonance (NMR).