1,4-Oxocin | 51153-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奥昔康唑
• 英文名称: 1,4-Oxocin
• 英文别名: 1,4-Dioxocin
• CAS: 51153-59-4
• 化学式: C₆H₆O₂
• 分子量: 110.112
• InChiKey: FAAFFBRUVXOHAE-FWNKLROWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.28
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1,4-Oxocin 、 丁炔二酸二甲酯 生成 methyl 7-oxanorborna-2,5-diene-2,3,5,6-tetracarboxylate 、 7-氧杂双环[2.2.1]庚-2,5-二烯-2,3-二甲酸二甲酯
  参考文献：
  名称：

  Breuninger, Manfred; Schwesinger, Reinhard; Gallenkamp, Bernd, Chemische Berichte, 1980, vol. 113, # 10, p. 3161 - 3186

  摘要：

  DOI：
• 作为产物：
  描述：

  cis-Benzoldioxid 生成 1,4-Oxocin
  参考文献：
  名称：

  Mueller, Klaus-Helmut; Kaiser, Clemens; Pillat, Michael, Chemische Berichte, 1983, vol. 116, # 7, p. 2492 - 2523

  摘要：

  DOI：

文献信息

• Diesel Composition and Method of Increasing Biodiesel Oxidation Stability
  申请人：Lin Jianmin

  公开号：US20120124896A1

  公开（公告）日：2012-05-24

  The present invention discloses a diesel composition, which comprises a base diesel and an additive composition, characterized in that said base diesel comprises biodiesel, and said additive composition comprises component (a) and component (b), wherein said component (a) is an arylamine-type antioxidant, and said component (b) is one or more polyamines or derivatives thereof. The diesel composition of the present invention has a superior oxidation stability.

  本发明揭示了一种柴油组合物，包括基础柴油和添加剂组合物，其特征在于所述基础柴油包括生物柴油，所述添加剂组合物包括组分（a）和组分（b），其中所述组分（a）是芳基胺类抗氧化剂，所述组分（b）是一种或多种聚胺或其衍生物。本发明的柴油组合物具有优异的氧化稳定性。
• COMPOUND ACTING AS ANTIBIOTICS
  申请人：KBP Biosciences Co., Ltd.

  公开号：EP3750881A1

  公开（公告）日：2020-12-16

  The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.

  本发明提供了一种由下式（I）表示的新型抗生素化合物、其药学上可接受的盐、酯、原药、溶液或其氘代类似物或其立体异构体。本发明的化合物具有优异的抗菌活性，特别是对革兰氏细菌。 其中各基团的定义与说明中的相同。
• Quinazoline derivatives substituted by aniline, preparation method and use thereof
  申请人：XUANZHU PHARMA CO., LTD.

  公开号：US10507209B2

  公开（公告）日：2019-12-17

  The invention relates to quinazoline derivatives substituted by aniline which are represented by the below formula (I), pharmaceutical acceptable salts and stereoisomer thereof, wherein these groups of R1, R2, R3, R4, R5, R6, L and n have the meanings given in the specification. The invention also relates to preparation methods, pharmaceutical compositions, pharmaceutical preparation and the use for preparation of medicine of treating excessive hyperplasia and chronic obstructive pulmonary disease and uses for treating excessive hyperplasia and chronic obstructive pulmonary disease thereof.

  本发明涉及由苯胺取代的喹唑啉衍生物，这些衍生物由下式(I)表示，其药物可接受盐和立体异构体，其中R1、R2、R3、R4、R5、R6、L和n这些基团具有说明书中给出的含义。本发明还涉及治疗过度增生和慢性阻塞性肺病药物的制备方法、药物组合物、药物制剂和制备用途及其治疗过度增生和慢性阻塞性肺病的用途。
• QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：EP2612860B1

  公开（公告）日：2017-03-15
• DIESEL COMPOSITION AND PROCESS FOR IMPROVING OXIDATION STABILITY OF BIODIESEL
  申请人：China Petroleum & Chemical Corporation

  公开号：EP2447344B1

  公开（公告）日：2019-07-24