potassium hydrogen persulfate | 13982-52-0

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 英文名称: potassium hydrogen persulfate
• 英文别名: Potassium hydrogenpersulfate；potassium;sulfooxy sulfate
• CAS: 13982-52-0
• 化学式: HO₈S₂*K
• 分子量: 232.233
• InChiKey: HDMGAZBPFLDBCX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2,3,5,6,7,8-hexahydro-2-phenyl-8-phenylthioimidazo[1,2-a]pyridine 、 potassium hydrogen persulfate 、 水 在 ice 、 氯仿 、 Sodium sulfate-III 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以to afford the sulfone as a yellowish oil in 92% yield的产率得到2,3,5,6,7,8-Hexahydro-2-phenyl-8-phenylsulfonylimidazo[1,2-a]pyridine sulfate
  参考文献：
  名称：

  Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines

  摘要：

  2-芳基、3-芳基和2,3-二芳基-2,5,6,7-四氢-3H-吡咯[1,2-a]-咪唑和2-芳基、3-芳基和2,3-二芳基-2,3,5,6,7,8-六氢-咪唑[1,2-a]-吡啶的7-醚和7-硫醚衍生物，例如2,3,5,6,7,8-六氢-2-苯基-8,8-二甲氧基-咪唑[1,2-a]吡啶盐酸盐，可用作免疫调节剂。

  公开号：

  US04507481A1

文献信息

• Derivatives of n-phenylpyrazoles
  申请人：Rhone-Poulenc Agriculture Ltd.

  公开号：US05608077A1

  公开（公告）日：1997-03-04

  N-Phenylpyrazole derivatives of the formula: ##STR1## wherein R.sup.1 represents cyano, nitro, halogen, acetyl or formyl; R.sup.2 represents R.sup.5 SO.sub.2, R.sup.5 SO or R.sup.5 S in which R.sup.5 is optionally halogen substituted alkyl, alkenyl or alkynyl; R.sup.3 represents a hydrogen atom or a group NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each represent hydrogen, alkyl, alkenylalkyl, alkynylalkyl, formyl, optionally halogen substituted alkanoyl, optionally halogen substituted alkoxycarbonyl, or alkoxymethyleneamino, halogen, or R.sup.6 and R.sup.7 together form a cyclic imide and R.sup.4 represents a substituted phenyl group possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.

  该文描述了公式为：##STR1##的N-苯基吡唑衍生物，其中R.sup.1代表氰基、硝基、卤素、乙酰基或甲酰基；R.sup.2代表R.sup.5 SO.sub.2、R.sup.5 SO或R.sup.5 S，其中R.sup.5是可选的卤素取代的烷基、烯基或炔基；R.sup.3代表氢原子或NR.sup.6 R.sup.7基团，其中R.sup.6和R.sup.7各代表氢、烷基、烯基烷基、炔基烷基、甲酰基、可选卤素取代的烷酰基、可选卤素取代的烷氧羰基或烷氧亚甲基氨基、卤素，或R.sup.6和R.sup.7一起形成一个环状亚酰胺，R.sup.4代表取代的苯基团，具有杀虫、植物线虫、驱虫和抗原虫活性；文中还描述了它们的制备、含有它们的组合物以及它们的用途。
• Cyclohexane derivatives
  申请人：Imperial Chemical Industries PLC

  公开号：US04736057A1

  公开（公告）日：1988-04-05

  This invention concerns novel (4-substituted-2-phenylcyclohexyl)alkenoic and alkanoic acid derivatives of the formula I wherein one of Ra and Rb is hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)alkenyloxy or phenyl(1-4C)alkoxy and the other of Ra and Rb is hydrogen, (1-6C)alkyl, (1-6C)alkoxy or (3-6C)alkenyloxy; or Ra and Rb together form a (2-4C)alkylenedioxy or oxo group; benzene ring X optionally bears a substituent selected from halogeno, (1-6C)alkyl, (1-6C)alkoxy, hydroxy, (2-6C)alkanoyloxy, (1-6C)alkanoylamino, trifluoromethyl and nitro; n is 3-5; Y is ethylene or vinylene; and in the cyclohexane ring, the substituents at positions 1 and 2 have cis- or trans-relative stereochemistry; and the pharmaceutically acceptable salts, (1-6C)alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I possess valuable pharmacological properties of use in medicines. The invention also concerns processes for the manufacture of, and pharmaceutical compositions containing a novel compound of formula I.

  该发明涉及公式I的新型（4-取代-2-苯基环己基）烯酸和烷酸衍生物，其中Ra和Rb中的一个是氢，羟基，（1-6C）烷基，（1-6C）烷氧基，（3-6C）烯氧基或苯基（1-4C）烷氧基，而Ra和Rb的另一个是氢，（1-6C）烷基，（1-6C）烷氧基或（3-6C）烯氧基；或Ra和Rb在一起形成（2-4C）烷二氧基或氧代基；苯环X可选地带有卤素，（1-6C）烷基，（1-6C）烷氧基，羟基，（2-6C）酰氧基，（1-6C）酰胺基，三氟甲基和硝基中的一种取代基；n为3-5；Y为乙烯或乙烯基；在环己烷环中，位置1和2的取代基具有顺式或反式相对立体化学；以及其药学上可接受的盐，（1-6C）烷基酯和（1-6C）烷磺酰胺。公式I的化合物具有用于药物的有价值的药理学特性。该发明还涉及制造公式I的新型化合物的方法和含有该化合物的制药组合物。
• Derivatives of N-phenylpyrazoles
  申请人：——

  公开号：US05232940A1

  公开（公告）日：1993-08-03

  N-Phenylpyrazole derivatives of the formula: ##STR1## wherein R.sup.1 represents cyano, nitro, halogen, acetyl or formyl; R.sup.2 represents R.sup.5 SO.sub.2, R.sup.5 SO or R.sup.5 S in which R.sup.5 is optionally halogen substituted alkyl, alkenyl or alkynyl; R.sup.3 represents a hydrogen atom or a group NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each represent hydrogen, alkyl, alkenylalkyl, alkynylalkyl, formyl, optionally halogen substituted alkanoyl, optionally halogen substituted alkoxycarbonyl, or alkoxymethyleneamino, halogen, or R.sup.6 and R.sup.7 together form a cyclic imide and R.sup.4 represents a substituted phenyl group possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.

  N-苯基吡唑衍生物的化学式为：##STR1## 其中R.sup.1代表氰基、硝基、卤素、乙酰基或甲酰基；R.sup.2代表R.sup.5 SO.sub.2、R.sup.5 SO或R.sup.5 S，其中R.sup.5是可选的卤素取代的烷基、烯基或炔基；R.sup.3代表氢原子或NR.sup.6 R.sup.7基团，其中R.sup.6和R.sup.7分别代表氢、烷基、烯基烷基、炔基烷基、甲酰基、可选的卤素取代的烷酰基、可选的卤素取代的烷氧羰基、或烷氧亚甲基氨基、卤素，或R.sup.6和R.sup.7一起形成环状亚酰胺，R.sup.4代表取代苯基团，具有杀虫、植物线虫、驱虫和抗原虫性能；描述了它们的制备、含有它们的组合物以及它们的用途。
• Process for preparing pyrrolo[1,2-a]imidazoles and
  申请人：Pennwalt Corporation

  公开号：US04560758A1

  公开（公告）日：1985-12-24

  The instantly claimed invention is a process for preparing a 3-aryl or a 2,3-diaryl-2,5,6,7-tetrahydro-3H-pyrrole[1,2-a]imidazole or a 3-aryl or a 2,3-diaryl-2,3,5,6,7,8-hexa-hydroimidazo[1,2-a]pyridine which comprises (a) contacting the acid addition salt of the corresponding cyclic methylthioimine with a 2-aryl or a 2,3-diarylaziridine and (b) recovering from the resultant reaction mixture the desired compound, useful as immunomodulators.

  该项即时声明的发明是一种制备3-芳基或2,3-二芳基-2,5,6,7-四氢-3H-吡咯[1,2-a]咪唑或3-芳基或2,3-二芳基-2,3,5,6,7,8-六氢咪唑[1,2-a]吡啶的过程，包括(a)将相应的环状甲硫基亚胺的酸加成盐与2-芳基或2,3-二芳基环氧丙烷接触，(b)从所得的反应混合物中回收所需化合物，可用作免疫调节剂。
• C2-substituted idan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：——

  公开号：US20030130345A1

  公开（公告）日：2003-07-10

  Embodiments of the invention relate to C2-substituted indan-1-ones and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention include compounds of formula I 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.

  本发明的实施例涉及C2-取代的茚-1-酮及其生理上可接受的盐和生理上功能衍生物。本发明的化合物包括式I1的化合物，其中基团如定义所述，以及它们的生理上可接受的盐和制备它们的方法。例如，这些化合物适用于用作抑制食欲的药物。