高血压蛋白原酶 | 148465-73-0

• 分子结构分类: 水解酶 - 作用于肽键（肽酶） - 天冬氨酸内肽酶
• 中文名称: 高血压蛋白原酶
• 中文别名: 凝乳酶
• 英文名称: mucorpepsin
• 英文别名: Mucor rennin；Mucor aspartic proteinase；Mucor acid proteinase；Mucor acid protease；Mucor miehei aspartic proteinase；Mucor miehei aspartic protease；Mucor pusillus emporase；Fromase 100；Mucor pusillus rennin；Fromase 46TL；Mucor miehei rennin；Mucor meihei lipase
• CAS: 148465-73-0

反应信息

• 作为试剂：
  描述：

  3-hydroxy-4-(2-allylphenoxy)butanenitrile 、 乙酸乙烯酯 在 高血压蛋白原酶 作用下， 以 异丙醚 为溶剂， 反应 111.0h， 以44%的产率得到(R)-3-acetyloxy-4-(2-allylphenoxy)butanenitrile
  参考文献：
  名称：

  New chemoenzymatic pathway for β-adrenergic blocking agents

  摘要：

  The lipase mediated kinetic resolution of pharmaceutically important beta-hydroxy nitrites is described in high enantionteric excesses and good yields. Some of the chiral beta-hydroxy nitriles have been employed in the synthesis of P-adrenergic blocking agents such as propranolol, alprenolol and moprolol. This protocol has also been extended for the enantiopure preparation of 5-(4-tosyloxymethyl)-1,3-oxazolidine-2-one and 3-liydroxy-4-tosyloxybutaiieiiitrile, chiral intermediates of high synthetic value. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.02.015