三硼三氢氧化物 | 14213-97-9

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 各种混合金属/非金属
• 中文名称: 三硼三氢氧化物
• 英文名称: borate
• 英文别名: meta-borate；borate ion；borate(3-)
• CAS: 14213-97-9
• 化学式: BO₃
• 分子量: 58.8092
• InChiKey: BTBUEUYNUDRHOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.95
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  scyllo-inositol 、 三硼三氢氧化物 以 not given 为溶剂， 生成 Dinatrium-dihydroxy-{scyllo-inositolato(6-)-diborat(2-)}
  参考文献：
  名称：

  Posternak, Th.; Lucken, E. A. C.; Szente, A., Helvetica Chimica Acta, 1967, vol. 50, p. 326 - 330

  摘要：

  DOI：
• 作为产物：
  描述：

  在 H₂O or acid 作用下， 生成 三硼三氢氧化物
  参考文献：
  名称：

  Privalov, V. I.; Rigin, V. I.; Simkin, N. M., Neorganicheskie Materialy, 1977, vol. 13, p. 1530 - 1531

  摘要：

  DOI：
• 作为试剂：
  描述：

  联大茴香胺 、 sodium hydroxide 在 三硼三氢氧化物 作用下， 反应 16.5h， 生成 2-萘酚
  参考文献：
  名称：

  Bonding proteins to inorganic supports

  摘要：

  蛋白质，例如酶或抗体，可以通过中间残基o-二甲氧基苯胺，在各种无机支持体上以生物活性状态固定。

  公开号：

  US03983000A1

文献信息

• 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
  申请人：——

  公开号：US20020188018A1

  公开（公告）日：2002-12-12

  This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): 1 that are inhibitors of glycogen synthase kinase -3&bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

  本发明涉及糖原合成酶激酶-3β的抑制剂，治疗由Th2细胞因子过多引起的疾病的方法，以及公式（I）的3-吲哚基-4-苯基-1H-吡咯-2,5-二酮衍生物，它们是糖原合成酶激酶-3β的抑制剂，含有它们的制药组合物，使用它们的方法以及制备这些化合物的方法。
• Modulators of LXR
  申请人：Bayne D. Christopher

  公开号：US20050080111A1

  公开（公告）日：2005-04-14

  Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

  本发明的化合物，例如式（I）的化合物：其中n、m、A、B、R1、R2、R3、R4和R5如本文所定义，可用作肝X受体活性调节剂。还揭示了含有这些化合物的制药组合物和使用这些化合物的方法。
• Method and kit for enzymatically determining the pH of a specimen
  申请人：Diagnostic Reagents, Inc.

  公开号：US05595867A1

  公开（公告）日：1997-01-21

  The present invention concerns a method of enzymatically determining the pH of a specimen (e.g., a solution or a biological fluid) and a kit for conducting the method. The present method involves mixing (1) a specimen with (2) an enzyme and (3) one or more substrates for the enzyme in a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen; determining the activity of the enzyme; and correlating the activity of the enzyme to the pH of the specimen. Each of the sample, the enzyme, the substrate and the buffered solution is present in an amount effective to provide the direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present kit contains an enzyme, one or more substrates for the enzyme present in an amount effective to determine the enzyme activity, and a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present invention is particularly applicable to detecting adulteration of a urine specimen.

  本发明涉及一种酶法测定标本（例如溶液或生物流体）pH值的方法和用于进行该方法的试剂盒。本方法涉及将（1）标本与（2）酶以及（3）一种或多种酶底物混合在缓冲溶液中，其pH值有效地提供酶活性和标本pH值之间的直接比例关系；测定酶活性；并将酶活性与标本pH值相关联。样品、酶、底物和缓冲溶液的每个成分均以有效量存在，以提供酶活性和标本pH值之间的直接比例关系。本试剂盒包含一种酶，一种或多种酶底物，其成分量有效地确定酶活性，以及具有pH值有效地提供酶活性和标本pH值之间的直接比例关系的缓冲溶液。本发明特别适用于检测尿标本的掺假。
• High melt strength polymers and method of making same
  申请人：The Dow Chemical Company

  公开号：US20030065097A1

  公开（公告）日：2003-04-03

  A polymer composition comprises: (a) a high molecular weight, branched component; and (b) a low molecular weight, branched component. Some polymer compositions are characterized by a substantial absent of amyl or methyl branches and a melt strength (MS) that satisfies the following relationship: 1 M ⁢ ⁢ S ≥ x I 2 + y where x is greater than or equal to about 12.5 and y is greater than or equal to about 3. Some polymers are characterized by a melt strength (MS) that satisfies the following relationship: 2 M ⁢ ⁢ S ≥ x I 2 + y where x is greater than or equal to about 3 and y is greater than or equal to about 4.5 and a molecular weight distribution of greater than 3. A process for making polymers is also disclosed.

  一种聚合物组合物包括：（a）高分子量的分支组分；和（b）低分子量的分支组分。一些聚合物组合物的特征是缺乏明显的戊基或甲基分支以及熔融强度（MS）满足以下关系式：1M＆it;⁢S≥xI2+y，其中x大于或等于约12.5，y大于或等于约3。某些聚合物的特征是熔融强度（MS）满足以下关系式：2M＆it;⁢S≥xI2+y，其中x大于或等于约3，y大于或等于约4.5，并且分子量分布大于3。还公开了一种制备聚合物的过程。
• Combination regimens using progesterone receptor modulators
  申请人：WYETH

  公开号：US20030045511A1

  公开（公告）日：2003-03-06

  This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: 1 wherein R 1 and R 2 may be single substituents or fused; R 3 is H, OH, NH 2 , C 1 to C 6 alkyl, COR C , or optionally substituted C 1 to C 6 alkyl, C 3 to C 6 alkenyl, or alkynyl; R C is H, or optionally substituted C 1 to C 3 alkyl, aryl, C 1 to C 3 alkoxy, or C 1 to C 3 aminoalkyl; R 4 is H, halogen, CN, NO 2 , or optionally substituted C 1 to C 6 alkyl, alkynyl, C 1 to C 6 alkoxy, amino, or C 1 to C 6 aminoalkyl; and R 5 is a benzene ring, a five or six membered heterocyclic ring; or pharmaceutically acceptable salt thereof. Methods of treatment include contraception, secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, carcinomas, adenocarcinomas minimization of side effects, or food intake stimulation.

  本发明涉及使用取代的吲哚啉衍生物化合物进行环状联合疗法和方案，这些化合物是孕激素受体拮抗剂，具有以下一般结构：1其中，R1和R2可以是单一取代基或融合基；R3为H、OH、NH2、C1到C6烷基、CORC或可选取代的C1到C6烷基、C3到C6烯基或炔基；RC为H或可选取代的C1到C3烷基、芳基、C1到C3烷氧基或C1到C3氨基烷基；R4为H、卤素、CN、NO2或可选取代的C1到C6烷基、炔基、C1到C6烷氧基、氨基或C1到C6氨基烷基；R5为苯环、五元或六元杂环环；或其药学上可接受的盐。治疗方法包括避孕、继发性闭经、功能性出血、子宫平滑肌瘤、子宫内膜异位症、多囊卵巢综合症、癌症、腺癌、副作用最小化或食欲刺激。