2,3,6,7-tetrahydroimidazo[2,1-b]thiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 2,3,6,7-tetrahydroimidazo[2,1-b]thiazine
• 英文别名: 3,5,6,7-tetrahydro-2H-imidazo[2,1-b][1,3]thiazine
• 化学式: C₆H₁₀N₂S
• 分子量: 142.225
• InChiKey: OAJHUPAFXARZGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,6,7-tetrahydroimidazo[2,1-b]thiazine 、 bis(4-(1-pyrrolidino)phenyl)methylium tetrafluoroborate 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Nucleophilicities and Lewis Basicities of Isothiourea Derivatives

  摘要：

  Rate and equilibrium constants for the reactions of a series of isothioureas with benzhydrylium ions have been measured photometrically. The data were employed to determine the nucleophilicities and nucleofugalities of isothioureas and compare them with those of other organocatalysts.

  DOI：

  10.1021/jo200803x
• 作为产物：
  描述：

  亚乙基硫脲 、 1,3-二溴丙烷 在 sodium carbonate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以73%的产率得到2,3,6,7-tetrahydroimidazo[2,1-b]thiazine
  参考文献：
  名称：

  Nonaromatic Amidine Derivatives as Acylation Catalysts

  摘要：

  Catalytic activity of nonaromatic bicyclic amidines and bicyclic isothioureas in acylation reactions was found to be remarkably dependent on the sizes of both rings. DBN and especially its thia-analogue (THTP) have been identified as highly active acylation catalysts.

  DOI：

  10.1021/ol0623419

文献信息

• CURABLE COMPOSITION COMPRISING DUAL REACTIVE SILANE FUNCTIONALITY
  申请人：Yang Yu

  公开号：US20130102728A1

  公开（公告）日：2013-04-25

  A curable composition comprises (a) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydrosilyl moiety; (b) at least one inorganic or organic compound comprising reactive silane functionality comprising at least one hydroxysilyl moiety, the hydroxysilyl moiety optionally being generated in situ by hydrolysis of at least one hydrosilyl moiety; and (c) at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof; with the proviso that, when component (a) is an organic polymer, then component (b) is different from component (a) and is not generated in situ by hydrolysis of component (a).

  一种可治愈的组合物包括：（a）至少一种含有反应性硅烷官能团的无机或有机化合物，其中该反应性硅烷官能团包括至少一个氢硅烷基；（b）至少一种含有反应性硅烷官能团的无机或有机化合物，其中该反应性硅烷官能团包括至少一个羟基硅烷基，该羟基硅烷基可以通过至少一个氢硅烷基的水解而在原位生成；以及（c）选自氨基甲酸酰胺、鸟氨酸、磷氮化物、丙磺酰膦杂环戊烷和其组合物中的至少一种碱，但当组分（a）为有机聚合物时，则组分（b）与组分（a）不同且不是通过组分（a）的水解在原位生成的。
• US8841399B2
  申请人：——

  公开号：US8841399B2

  公开（公告）日：2014-09-23
• Nonaromatic Amidine Derivatives as Acylation Catalysts
  作者：Vladimir B. Birman、Ximin Li、Zhenfu Han

  DOI：10.1021/ol0623419

  日期：2007.1.1

  Catalytic activity of nonaromatic bicyclic amidines and bicyclic isothioureas in acylation reactions was found to be remarkably dependent on the sizes of both rings. DBN and especially its thia-analogue (THTP) have been identified as highly active acylation catalysts.
• Nucleophilicities and Lewis Basicities of Isothiourea Derivatives
  作者：Biplab Maji、Caroline Joannesse、Tobias A. Nigst、Andrew D. Smith、Herbert Mayr

  DOI：10.1021/jo200803x

  日期：2011.6.17

  Rate and equilibrium constants for the reactions of a series of isothioureas with benzhydrylium ions have been measured photometrically. The data were employed to determine the nucleophilicities and nucleofugalities of isothioureas and compare them with those of other organocatalysts.