氧化钒 | 12035-98-2

• 物质功能分类: 无机化工 - 氧化物和过氧化物 - 金属氧化物
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 氧化钒
• 英文名称: oxovanadium(IV)
• 英文别名: oxo-vanadium；vanadium oxide；oxovanadium；Vanadium(II) oxide
• CAS: 12035-98-2；12037-42-2；12037-05-7
• 化学式: OV
• 分子量: 66.9409
• InChiKey: IBYSTTGVDIFUAY-UHFFFAOYSA-N

物化性质

• 熔点：
  950℃
• 密度：
  5.758
• 溶解度：
  溶于酸溶液
• 物理描述：
  Light gray crystalline solid; Insoluble in water; [MSDSonline]

计算性质

• 辛醇/水分配系数(LogP)：
  -0.12
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

钒主要通过吸入被吸收，尽管少量可以通过皮肤和消化道吸收。它在血浆中迅速分布，主要分布到肾脏、肝脏、肺、心脏、骨骼等部位，并倾向于在这些部位积累。在细胞色素P-450酶的帮助下，钒可以在其两种氧化态之间相互转化，即钒(IV)（V+4）和钒酸根（V+5）。钒的这两种状态都可以可逆地与血液中的转铁蛋白结合，然后被红细胞摄取。钒主要通过尿液排出体外。(L837)

Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

钒通过降低巨噬细胞膜的完整性来损害肺泡巨噬细胞，从而影响细胞的吞噬能力和生存能力。钒的五价形式，钒酸盐，是细胞膜上Ca2+-ATP酶和Na+,K+-ATP酶的强效抑制剂，这会降低细胞内ATP的浓度。还认为钒能诱导活性氧种类的产生。这可能损害DNA并导致氧化应激，从而损害生殖系统。钒还能抑制蛋白质酪氨酸磷酸酶，产生类似胰岛素的效果。

Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

吸入高浓度的钒会影响肺部、喉咙和眼睛。摄入钒可能会导致肾脏和肝脏损伤、出生缺陷或死亡。

Breathing high levels of vanadium affects the lungs, throat, and eyes. Ingestion of vanadium may cause kidney and liver damage, birth defects, or death. (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L837）；吸入（L837）；皮肤给药（L837）

Oral (L837) ; inhalation (L837) ; dermal (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

吸入钒会导致肺部刺激、咳嗽、喘息、胸痛、流鼻涕和喉咙痛。

Inhalation of vanadium causes lung irritation, coughing, wheezing, chest pain, runny nose, and a sore throat. (L837)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• TSCA：
  Yes
• 危险等级：
  6.1
• 海关编码：
  2825309000
• 包装等级：
  II
• 危险类别：
  6.1
• 危险品运输编号：
  UN3285

反应信息

• 作为反应物：
  描述：

  氧气 、 氧化钒 以 gaseous matrix 为溶剂， 生成 vanadium dioxide
  参考文献：
  名称：

  Kinetics of the reactions VO(X 4Σ−)+O2, NO, and CO2

  摘要：

  The kinetics are reported for the gas-phase reactions of VO(X4SIGMA-) with O2, NO, and CO2 at 297, 394, and 531 K, and at total pressures up to 165 Torr using argon bath gas. VO was produced by the multiphoton dissociation of VOCl3(g) at 193 nm and was detected by laser-induced fluorescence. Measured rate constants for all reactions exhibited a slight negative temperature dependence, and only the VO + NO reaction was found to be pressure dependent. Results are interpreted in terms of the reactions going through an intermediate which subsequently falls apart to VO2 or collisionally stabilizes.

  DOI：

  10.1016/0009-2614(93)89290-x
• 作为产物：
  描述：

  三氯一氧化钒 三氯代氧化钒(V) 以 gaseous matrix 为溶剂， 生成 氧化钒
  参考文献：
  名称：

  VO 的傅里叶变换光谱：A4Π-X4Σ− 系统中接近 10 500 Å 的旋转结构

  摘要：

  摘要 VO 在近红外区域的 A4Π-X4Σ− 电子跃迁通过傅立叶变换光谱以多普勒限制分辨率记录，并对 1.05 μm 处的 (0, 0) 波段和1.18 微米。发现 A4Π 状态具有相对较小的自旋轨道耦合（A = 35.19 cm-1），因此在观察到的最高 N 值（N = 90 附近）几乎完全不耦合到情况 (b)。超精细结构由于51V 核（ I = 7 2 ）在 4 Π 5 2 -X 4 Σ - 子带和许多自旋卫星分支中很突出；在高 N 值下，只有主要分支 (ΔN = ΔJ) 出现，线条很尖锐，表明超精细 b 参数（磁性超精细哈密顿量中的 I·S 系数）在 A4Π 和 X4Σ− 状态下相同.

  DOI：

  10.1016/0022-2852(82)90110-2
• 作为试剂：
  描述：

  DL-扁桃酸甲酯 在 zinc(II) nitrate 、 氧化钒 作用下， 以 乙腈 为溶剂， 80.0 ℃ 、200.0 kPa 条件下， 反应 4.0h， 生成 苯丙酮
  参考文献：
  名称：

  一种催化氧化扁桃酸酯制备苯乙酮酸酯的方 法

  摘要：

  本发明属于制备苯乙酮酸酯的技术领域，提供了一种催化氧化扁桃酸酯制备苯乙酮酸酯的方法，该方法以含氧气体作为氧化剂，钒氧化合物、过渡金属硝酸盐两种组分作为复合催化剂，在30‑150℃温和反应条件下，扁桃酸酯经一步氧化制得苯乙酮酸酯。与傅克酰基化法、苯甲酰腈水解法、苯乙烯氧化法等合成方法相比，该方法反应步骤少、操作简单、反应条件温和、绿色环保、催化剂廉价高效，具有较好的应用前景和较高的实用价值。

  公开号：

  CN108503545B

文献信息

• Design nano azo chelates containing barbituric acid and o-amino benzoic acid spectral, thermal investigation, modelling and biological activity
  作者：Shimaa G. Hussien、Basma Ghazal、Mamdouh S. Masoud、Sanaa M. Emam、Ahmed El-Hamalawy、Saeyda A. Abouel-Enein

  DOI：10.1016/j.molstruc.2022.132698

  日期：2022.7

  metal ions Ti(IV), VO(II), Mn(II), Fe(III), Cu(II) Zr(IV), Ru(III), Ag(I) and Hf(IV). The structure of all prepared compounds were identified based on physicochemical, spectral and thermal techniques. The complexes were separated with 1:1 and 1:2 (M:L) stoichiometry. All chelates were non-electrolyte except Fe(III), Zr(IV), Ru(III), Ag(I) and Hf(IV) had electrolytic nature. All complexes constructed

  偶氮配体2-((2,4,6-三氧代六氢嘧啶-5-基)二氮烯基)苯甲酸(H 3 L)用于与不同价金属离子 Ti(IV)、VO(II)、Mn(II)、Fe(III)、Cu(II) Zr(IV)、Ru(III)、Ag(I) 和 Hf(四）。基于物理化学、光谱和热技术鉴定所有制备化合物的结构。配合物以 1:1 和 1:2 (M:L) 化学计量分离。除 Fe(III)、Zr(IV)、Ru(III)、Ag(I) 和 Hf(IV) 具有电解性质外，所有螯合物均为非电解质。除钒基、锰、铜和银配合物分别设计为方锥体和四坐标结构外，所有配合物均构造为八面体几何结构。红外研究证实偶氮染料配体作为中性双齿通过偶氮基团的氮原子和羧基部分的(OH)与金属离子配位。所有配合物的热行为均通过热重法（TG，DTG）进行了验证。配合物比配体表现出更高的热稳定性。XRD 和 TEM 研究表明，所有化合物均以纳米颗粒尺寸形成。此外，使用
• Crossed‐beam chemiluminescent reactions of titanium and vanadium with O₂
  作者：J. M. Parson、L. C. Geiger、T. J. Conway

  DOI：10.1063/1.440922

  日期：1981.5.15

  Titanium and vanadium have been reacted with O2 under crossed-beam conditions to form the TiO A 3Φ, B 3Π, C 3Δ, and E 3Π states and the VO B 4Π state. By heating and seeding the O2 nozzle beam the Ti reaction has been studied at relative collision energies of 4.0, 7.6, and 13.3 kcal/mol, and the V reaction at 3.9, 6.9, 7.6, and 13.1 kcal/mol. Computer simulations of the spectra yield relative rates for formation of TiO(A) and VO(B) vibrational states, which are slightly more excited than the ’’prior’’ model predictions. Increasing the relative collision energy does increase the production of all the electronically excited states, but the VO B state population does not increase as quickly as expected from the prior model. The dependence of the chemiluminescent signals on the metal source temperature suggests reaction of ground state Ti to form TiO(A), but metastable V to form VO (B).
• Fourier transform spectroscopy of VO: Rotational structure in the A4Π-X4Σ− system near 10 500 Å
  作者：A.S-C. Cheung、A.W. Taylor、A.J. Merer

  DOI：10.1016/0022-2852(82)90110-2

  日期：1982.4

  near N = 90. The hyperfine structure due to the 51V nucleus ( I = 7 2 ) is prominent in the 4 Π 5 2 -X 4 Σ − subband, and in many of the spin satellite branches; at high N values, where only main branches (ΔN = ΔJ) occur, the lines are sharp, indicating that the hyperfine b parameter (the coefficient of I·S in the magnetic hyperfine Hamiltonian) is the same in the A4Π and X4Σ− states. The electron configuration

  摘要 VO 在近红外区域的 A4Π-X4Σ− 电子跃迁通过傅立叶变换光谱以多普勒限制分辨率记录，并对 1.05 μm 处的 (0, 0) 波段和1.18 微米。发现 A4Π 状态具有相对较小的自旋轨道耦合（A = 35.19 cm-1），因此在观察到的最高 N 值（N = 90 附近）几乎完全不耦合到情况 (b)。超精细结构由于51V 核（ I = 7 2 ）在 4 Π 5 2 -X 4 Σ - 子带和许多自旋卫星分支中很突出；在高 N 值下，只有主要分支 (ΔN = ΔJ) 出现，线条很尖锐，表明超精细 b 参数（磁性超精细哈密顿量中的 I·S 系数）在 A4Π 和 X4Σ− 状态下相同.
• Kinetics of the reactions VO(X 4Σ−)+O2, NO, and CO2
  作者：Roy E. McClean、Louise Pasternack

  DOI：10.1016/0009-2614(93)89290-x

  日期：1993.11

  The kinetics are reported for the gas-phase reactions of VO(X4SIGMA-) with O2, NO, and CO2 at 297, 394, and 531 K, and at total pressures up to 165 Torr using argon bath gas. VO was produced by the multiphoton dissociation of VOCl3(g) at 193 nm and was detected by laser-induced fluorescence. Measured rate constants for all reactions exhibited a slight negative temperature dependence, and only the VO + NO reaction was found to be pressure dependent. Results are interpreted in terms of the reactions going through an intermediate which subsequently falls apart to VO2 or collisionally stabilizes.