氧化银(II) | 155645-89-9

• 物质功能分类: 无机化工 - 无机盐 - 胶态贵金属及其化合物
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 氧化银(II)
• 中文别名: 过氧化银；氧化银
• 英文名称: silver monoxide
• 英文别名: argentic oxide；Silver(II) oxide；oxosilver
• CAS: 155645-89-9；1301-96-8；155645-82-2
• 化学式: AgO
• 分子量: 123.868
• InChiKey: OTCVAHKKMMUFAY-UHFFFAOYSA-N

物化性质

• 熔点：
  100 °C
• 密度：
  7.483 g/mL at 25 °C
• 溶解度：
  溶于碱性溶液；与酸溶液发生反应

计算性质

• 辛醇/水分配系数(LogP)：
  -0.12
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

银及其化合物可以通过吸入被吸收，而银化合物也可以通过口服和皮肤接触被吸收。银在血液中分布到全身，尤其是肝脏。不溶的银盐转化为可溶的银硫化蛋白盐，与RNA、DNA和蛋白质中的氨基酸或羧基团结合，或者被抗坏血酸或儿茶酚胺还原成金属银。金属银被氧化，可能会沉积在组织中，导致银质沉着病。银主要通过粪便排出体外。

Silver and its compounds can be absorbed via inhalation, while silver compounds can also be absorbed orally and dermally. It distributes throughout the body in the blood, particularily to the liver. Insoluble silver salts are transformed into soluble silver sulfide albuminates, bind to amino or carboxyl groups in RNA, DNA, and proteins, or are reduced to metallic silver by ascorbic acid or catecholamines. Metallic silver is oxidized and may deposit in the tissues, causing arygria. Silver is eliminated primarily in the faeces. (L808)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

金属银被氧化并可能在组织中沉积，导致银质沉着病。银离子已知可以抑制谷胱甘肽过氧化物酶和Na+,K+-ATP酶的活性，分别干扰硒催化的巯基氧化还原反应和细胞内离子浓度。银纳米颗粒被认为会破坏线粒体呼吸链，导致氧化应激、ATP合成减少和DNA损伤。

Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (L808, A243, A244, A245, A246)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

银本身对人类并不有毒，但大多数银盐都有毒。在大剂量下，银及其化合物可以被吸收进入循环系统，并在各种身体组织中沉积，导致银质病，这种病症会导致皮肤、眼睛和粘膜呈现蓝灰色的色素沉着。银质病是罕见的，尽管据目前所知，这种状况并不会对人的健康造成其他伤害，但它会毁容并且通常是永久性的。银质病的轻微形式有时会被误认为是发绀。

Silver itself is not toxic to humans, but most silver salts are. In large doses, silver and compounds containing it can be absorbed into the circulatory system and become deposited in various body tissues, leading to argyria, which results in a blue-grayish pigmentation of the skin, eyes, and mucous membranes. Argyria is rare, and although, so far as known, this condition does not otherwise harm a person's health, it is disfiguring and usually permanent. Mild forms of argyria are sometimes mistaken for cyanosis. (L809)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L808）；吸入（L808）；皮肤给药（L808）

Oral (L808) ; inhalation (L808) ; dermal (L808)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

长时间接触高水平的银可能会导致一种称为银质病（argyria）的状况，这是一种皮肤和其他身体组织的蓝灰色色素沉着。银质病是一种永久性的影响，但似乎对健康无害。空气中高水平银的暴露导致了呼吸问题、肺和喉咙刺激以及胃痛。银与皮肤的接触可能会在某些人中引起轻微的过敏反应，如皮疹、肿胀和炎症。（L808）

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• TSCA：
  Yes
• 危险等级：
  5.1

反应信息

• 作为反应物：
  描述：

  氧化银(II) 、 柠檬酸 生成 Silver citrate
  参考文献：
  名称：

  ANTIMICROBIAL SILVER SOLUTIONS

  摘要：

  一种制备含水、柠檬酸盐离子和银离子的浓缩溶液的方法，包括提供一定量的三银柠檬酸盐、提供一定量的柠檬酸，其中柠檬酸的重量至少是三银柠檬酸盐的19倍，并将三银柠檬酸盐和柠檬酸混合在一定量的水中，以产生浓缩溶液，其中所选用的水的量使得浓缩溶液的柠檬酸盐浓度至少为每升300克。一种含水、柠檬酸盐离子和银离子的浓缩溶液，其中浓缩溶液的银离子浓度至少为每升10克。通过向含水、柠檬酸盐离子和银离子的浓缩溶液中加水制备的稀释溶液。

  公开号：

  US20100040699A1
• 作为产物：
  描述：

  氧气 、 银 以 gaseous matrix 为溶剂， 生成 氧化银(II)
  参考文献：
  名称：

  The millimeter wave spectrum of silver monoxide, AgO

  摘要：

  The pure rotational spectra of AgO107 and AgO109 were recorded in the 117–380 GHz spectral region using a dc-sputtering absorption cell. The Ag107(I=1/2) and Ag109(I=1/2) magnetic hyperfine parameters are interpreted in terms of plausible electronic configuration contributions to the X 2Πi state. It is shown that the determined unusual sign of the Λ-doubling and Fermi contact parameters implies that the X 2Πi state is dominated by a three open shell configuration. A comparison with isovalent CuO is made.

  DOI：

  10.1063/1.476196
• 作为试剂：
  描述：

  2-(1-(4-ethoxyphenyl)-2-oxo-4-styrylazetidin-3-yl)isoindoline-1,3-dione 在 氧化银(II) 、 硝酸 作用下， 以 1,4-二氧六环 为溶剂， 以88%的产率得到2-(2-oxo-4-styrylazetidin-3-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  Argentic oxide mediated N-dearylation of β-lactams

  摘要：

  A method is described for the N-dearylation of N-(4-methoxy- or 4-ethoxyphenyl)-2-azetidinones with argentic oxide. The yields are good-to-excellent and the reaction is simple, efficient, and fast. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.022

文献信息

• Catalyst for oxidation of ethylene to ethylene oxide
  申请人：Scientific Design Company, Inc.

  公开号：US05008413A1

  公开（公告）日：1991-04-16

  An improved silver catalyst for the oxidation of ethylene with molecular oxygen is made by impregnating a support with a silver salt prepared by reacting a silver compound with a neo-acid, in a hydrocarbon solvent with the reaction completed under reflux conditions; drying and activating the resultant precatalyst by heating in air; thereafter impregnating the activated catalyst with an amount, 800 to 5000 wppm of alkali metal, preferably Cs, to deactivate the catalyst to form a catalyst precursor and heating the catalyst precursor at 450.degree.-700.degree. C. for 0.1 to 4.5 hours at a steady state in a substantially inert atmosphere to reactivate it.

  改进的银催化剂用于乙烯和分子氧气的氧化反应，通过将载体浸渍在银盐中制成，所述银盐是通过将银化合物与新酸在烃溶剂中反应制备而成，在回流条件下完成反应；将得到的前催化剂干燥并在空气中加热激活；然后将激活的催化剂浸渍在碱金属的800至5000 wppm的量中，优选Cs，以失活催化剂形成催化剂前体，并在450°C至700°C的稳定状态下，在基本惰性气氛中进行0.1至4.5小时的加热反应，以再次激活它。
• Peptidase inhibitors
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US05496927A1

  公开（公告）日：1996-03-05

  This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.

  本发明涉及肽酶底物的类似物，其中底物肽的含有可切割酰胺键的酰胺基团已被活化的亲电性酮基团替换。这些肽酶底物的类似物为各种蛋白酶提供了特异性的酶抑制剂，抑制这些蛋白酶将在各种疾病状态下产生有用的生理后果。
• Chemical amplification type positive resist composition
  申请人：Takata Yoshiyuki

  公开号：US20050031984A1

  公开（公告）日：2005-02-10

  The present invention provides a resin which comprises a structural unit of the formula (I) wherein R 1 represents alkylene having 1 to 4 carbon atoms, R 2 represents alkyl having 1 to 4 carbon atoms, and R 3 represents hydrogen or methyl, and also prvides a chemical amplification type positive resist composition comprising a resin defined above and an acid generator.

  本发明提供了一种树脂，其包括式(I)的结构单元，其中R1代表具有1到4个碳原子的烷基，R2代表具有1到4个碳原子的烷基，R3代表氢或甲基，并且还提供了一种化学放大型正向感光阻剂组合物，该组合物包括上述定义的树脂和酸发生剂。
• Process for preparing silver catalysts
  申请人：The Halcon SD Group, Inc.

  公开号：US04555501A1

  公开（公告）日：1985-11-26

  A supported silver catalyst for the oxidation of ethylene to ethylene oxide with molecular oxygen is made by impregnating a support with a hydrocarbon solution of a silver salt of a neo-acid having 7 or more carbon atoms, substantially free of water and said neo-acid. Preferably, the hydrocarbon solvent is toluene, xylene, ethyl benzene, cyclohexane, or cumene. The impregnated support is dried and the silver is activated under conditions chosen to provide the optimum selectivity to ethylene oxide. Thereafter, the activated silver catalyst may be impregnated with an alkali metal solution sufficient to increase selectivity of the silver catalyst above its alkali-free state. The amount of alkali metal on the finished catalyst is the optimum for the particular support selected and preferably will be about 1-6.times.10.sup.-3 gew/kg of catalyst. The catalyst may also include additional promoters, such as the alkaline earth metals, preferably barium.

  使用一种支持银催化剂，通过将一种具有7个或更多碳原子的新酸的银盐的烃溶液浸渍到支持物中制备，该烃溶液基本上不含水和所述新酸。最好的烃溶剂是甲苯、二甲苯、乙基苯、环己烷或叔丁基苯。浸渍的支持物被干燥，然后银在选择最佳丙烯醛选择性的条件下被激活。此后，激活的银催化剂可以浸渍有足够的碱金属溶液以提高银催化剂在无碱状态下的选择性。成品催化剂上的碱金属的量是特定支持物选择的最佳值，最好约为1-6×10.sup.-3 gew/kg的催化剂。催化剂还可以包括其他促进剂，例如碱土金属，最好是钡。
• Amplification type positive resist composition
  申请人：——

  公开号：US20040029037A1

  公开（公告）日：2004-02-12

  The present invention provides a sulfonate of the formula (I′): 1 wherein Q 1 , Q 2 , Q 3 , Q 4 and Q 5 each independently represent hydrogen, alkyl having 1 to 16 carbon atoms, alkoxy having 1 to 16 carbon atoms, or electron attractive group, with the proviso that at least one of Q 1 , Q 2 , Q 3 , Q 4 and Q 5 represents alkyl having 3 to 16 carbon atoms or alkoxy having 3 to 16 carbon atoms, and at least one of Q 1 , Q 2 , Q 3 , Q 4 and Q 5 is electron attractive group; and A′ + represents a counter ion of the formula (IIa), (IIb), (IIc) or (IId) which are identified in the specification. The present invention also provides a chemical amplification type positive resist composition comprising a sulfonate of the formula (I) 2 wherein A + represents counter ion, and Q 1 , Q 2 , Q 3 , Q 4 and Q 5 are as defined above;and resin which contains a structural unit having an acid labile group and which itself is insoluble or poorly soluble in an alkali aqueous solution but becomes soluble in an alkali aqueous solution by the action of an acid.

  本发明提供了一种式(I')的磺酸盐：其中，Q1、Q2、Q3、Q4和Q5各自独立地表示氢、具有1至16个碳原子的烷基、具有1至16个碳原子的烷氧基或电子吸引基团，但至少有一个Q1、Q2、Q3、Q4和Q5表示具有3至16个碳原子的烷基或具有3至16个碳原子的烷氧基，且至少一个Q1、Q2、Q3、Q4和Q5是电子吸引基团；以及A'+表示规范中所确定的式(Ila)、(IIb)、(IIc)或(IId)的计数离子。本发明还提供了一种化学放大型正向光刻胶组合物，包括式(I)的磺酸盐，其中A+表示计数离子，Q1、Q2、Q3、Q4和Q5如上所定义；以及含有酸敏感基团的结构单元的树脂，该树脂本身在碱性水溶液中不溶或难溶，但在酸的作用下变得可溶于碱性水溶液中。