焦磷酸钠十水合物

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 中文名称: 焦磷酸钠十水合物
• 中文别名: 焦磷酸钠；十水焦磷酸钠
• 英文名称: tetrasodium;phosphonato phosphate;decahydrate
• 化学式: H20Na4O17P2
• 分子量: 446.06
• InChiKey: VZWGHDYJGOMEKT-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  -23.57
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  146
• 氢给体数：
  10
• 氢受体数：
  17

反应信息

• 作为反应物：
  描述：

  焦磷酸钠十水合物 、 、 三正丁胺 在 水 、 ice 、 乙醇 、 N,N-二甲基甲酰胺 作用下， 以 水 、 乙醇 为溶剂， 生成 Tributylamine hemidiphosphate
  参考文献：
  名称：

  MODIFIED NUCLEOTIDES

  摘要：

  本文提供了一种使用过渡金属和一个或多个膦配体将化合物中公式为R-O-烯丙基、R2N(烯丙基)、RNH(烯丙基)、RN(烯丙基)2或R-S-烯丙基的烯丙基基团替换为氢的方法。

  公开号：

  US20120095201A1

文献信息

• Alkynylamino-nucleotides
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05151507A1

  公开（公告）日：1992-09-29

  Alkynylamino-nucleotides and labeled alkynylaminonucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation. For some applications, longer, hydrophilic linkers are provided.

  提供了Alkynylamino-核苷酸和标记的Alkynylamino-核苷酸，例如，作为DNA测序的链终止底物，并提供了几个关键中间体和它们的制备过程。对于某些应用，还提供了更长的亲水性连接剂。
• Continuous process for phosphorylating starch
  申请人：National Starch and Chemical Corporation

  公开号：US04216310A1

  公开（公告）日：1980-08-05

  Starch is phosphorylated by a virtually pollution-free, continuous process whereby an aqueous reagent solution of a tripolyphosphate, orthophosphate or pyrophosphate salt or a mixture thereof is sprayed onto a moist starch cake on a rotary vacuum filter in an amount sufficient to achieve efficient impregnation of the starch cake without losing significant levels of salt to the effluent. In a preferred embodiment, the reagent solution contains alkali metal tripolyphosphate salt and is obtained by diluting a concentrated solution thereof. The thus-impregnated starch is subsequently dried and heat-reacted by known procedures to produce an orthophosphate starch monoester.

  淀粉可以通过一种几乎无污染的连续过程进行磷酸化，该过程中，将三聚磷酸盐、正磷酸盐或焦磷酸盐的水溶性试剂溶液或其混合物喷洒到旋转真空过滤器上的湿淀粉蛋糕上，以达到高效浸渍淀粉蛋糕的目的，同时不会使盐的水平显著降低。在一种优选实施方式中，试剂溶液含有碱金属三聚磷酸盐，并通过稀释浓缩溶液获得。随后，经过已知的程序对浸渍的淀粉进行干燥和热反应，以产生正磷酸酯淀粉。
• Method, system and reagents for DNA sequencing
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05242796A1

  公开（公告）日：1993-09-07

  A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Functions of the emitted energy are obtained which vary over the wavelengths of the closely spaced spectra in different senses and the functions ratioed, whereby the ratio is indicative of the identity of the DNA fragments. The emitting portion of the reporter-labeled DNA fragment is preferably one of a family of fluorescent dyes based on 9-carboxyethyl-6-hydroxy-3-oxo-3 H-xanthene. These xanthene dyes are covalently attached to the DNA fragments through the carboxylic acid functionality, preferably via an amide linkage. The dyes may be protected by including an alkoxy group at the 9-position. A spacer may be inserted between the dye and the amine. The fluorescent dye preferably is attached to the DNA chain terminators and provides many advantages. Thus only DNA sequencing fragments resulting from bona fide termination events will carry a reporter. The DNA sequencing may also be labeled using the xanthene dyes which have general utility as fluorescent labels. Also acyclonucleoside triphosphates are described as being useful as chain terminators in DNA sequencing using a modification of the Sanger method.

  本文描述了一种DNA测序系统和方法，用于检测不同激发染料标记的物种（DNA片段）分离后发出的辐射能量的存在，并且在时间和/或空间上，以及在波长密集的发射能量的物种的身份上，获得变化的发射能量的功能。通过对函数进行比率，比率表明DNA片段的身份。最好的发射染料标记DNA片段的发射部分是基于9-羧基乙基-6-羟基-3-氧代-3H-黄酮的荧光染料家族之一。这些黄酮染料通过羧酸功能与DNA片段共价连接，最好通过酰胺连接。染料可以通过在9位点包括烷氧基来保护。染料和胺之间可以插入一个间隔物。荧光染料最好连接到DNA链终止子上，并提供许多优点。因此，只有由真正终止事件产生的DNA测序片段才会携带报告者。DNA测序也可以使用具有荧光标记通用性的黄酮染料进行标记。此外，本文还介绍了使用Sanger方法的改进来使用无环核苷酸三磷酸盐作为DNA测序中的链终止剂的方法。
• Methods and composition for mineralizing and fluoridating calcified
  申请人：American Dental Association Health Foundation

  公开号：US06000341A1

  公开（公告）日：1999-12-14

  This invention involves new compositions and methods of use and delivery of amorphous calcium compounds such as: amorphous calcium phosphate (ACP), amorphous calcium phosphate fluoride (ACPF), amorphous calcium carbonate phosphate (ACCP), amorphous calcium carbonate phosphate fluoride (ACCPF), and amorphous calcium fluoride (ACF) for use in remineralizing and fluoridating teeth. These amorphous compounds or solutions which form the amorphous compounds or calcium phosphate jelly which forms the amorphous compounds, when applied either onto or into dental tissue to prevent and/or repair dental weaknesses such as dental caries, exposed roots and dentin sensitivity. The compounds have the highest solubilities, fastest formation rates and fastest conversion rates (to apatite) among all the calcium phosphates under physiological conditions. Moreover, in the presence to fluoride the amorphous compound convert rapidly to fluoride containing apatite.

  本发明涉及新的组合物和使用方法以及输送无定形钙化合物，例如：无定形磷酸钙（ACP），无定形磷酸钙氟化物（ACPF），无定形碳酸钙磷酸盐（ACCP），无定形碳酸钙磷酸氟化物（ACCPF）和无定形氟化钙（ACF）用于牙齿的再矿化和氟化。这些无定形化合物或形成无定形化合物的溶液或形成无定形化合物的磷酸钙凝胶，当施加于或进入牙齿组织以预防和/或修复牙齿的弱点，例如龋齿，暴露的根和牙本质敏感。这些化合物在生理条件下具有最高的溶解度、最快的形成速率和最快的转化速率（到磷灰石）。此外，在氟化物存在的情况下，无定形化合物会迅速转化为含氟磷灰石。
• Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use
  申请人：Pharmacia AB

  公开号：US06313132B1

  公开（公告）日：2001-11-06

  The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The compounds have anticholinergic activity, and the invention also relates to the compounds of Formula (I), the use of the compounds of Formula (I) for preparing anticholinergic drugs, the use of the compounds of Formula (I) for treating urinary tract incontinence, and methods for preparing the compounds of Formula (I).

  本发明涉及一种新型化合物，其化学式为(I)，其中R1，R2，R3，R4，R5，R6，R7和Ar如权利要求1所定义，它们与生理学上可接受的酸盐，以及当化合物可以存在光学异构体形式时，包括外消旋混合物和单体对映体。该化合物具有抗胆碱能活性，本发明还涉及化合物(I)，用于制备抗胆碱能药物的化合物(I)的用途，用于治疗尿失禁的化合物(I)的用途，以及制备化合物(I)的方法。

表征谱图