chloroethylthiomorpholine hydrochloride | 89583-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: chloroethylthiomorpholine hydrochloride
• 英文别名: 4-(2-chloro-ethyl)-thiomorpholine; hydrochloride；4-(2-Chlor-aethyl)-thiomorpholin; Hydrochlorid；N-(2-chloroethyl)thiomorpholine hydrochloride；4-(2-Chloroethyl)thiomorpholine hydrochloride；4-(2-chloroethyl)thiomorpholine;hydrochloride
• CAS: 89583-39-1
• 化学式: C₆H₁₂ClNS*ClH
• mdl: MFCD22196582
• 分子量: 202.148
• InChiKey: HVYUHTBJKBUBSH-UHFFFAOYSA-N

物化性质

• 熔点：
  210-212 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.22
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  chloroethylthiomorpholine hydrochloride 在 水 作用下， 生成 N-(2-羟乙基)吗啉
  参考文献：
  名称：

  4-Azabicyclo[2,2,2]octane-1-thionium Halides: A New Ring System¹

  摘要：

  DOI：

  10.1021/ja01607a050
• 作为产物：
  描述：

  hydrochloride salt of 4-(2-hydroxyethyl)-1,4-perhydrothiazine 在 氯化亚砜 、 苯 作用下， 生成 chloroethylthiomorpholine hydrochloride
  参考文献：
  名称：

  Potential Antiviral Agents. II. Analogs of Tetraalkyldiamines

  摘要：

  DOI：

  10.1021/ja01587a030

文献信息

• 4-SUBSTITUTED COUMARIN DERIVATIVES AND PREPARATION METHODS AND USES THEREOF
  申请人：CHEN Lijuan

  公开号：US20180282315A1

  公开（公告）日：2018-10-04

  The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells.

  本发明涉及化学药品领域，特别是4-取代香豆素衍生物及其制备方法和应用。该发明提供了具有如公式I所示结构式的4-取代香豆素衍生物。该发明还提供了上述4-取代香豆素衍生物的制备方法和应用。本发明提供的化合物在多种肿瘤细胞系中具有强大的抗肿瘤活性，IC50在0.01-5 nM之间，并且在抑制微管聚合方面表现更好，具有多样化的生物活性和低毒性，为药物敏感和耐药肿瘤细胞提供了新选择。
• [EN] C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY<br/>[FR] TRITERPÉNOÏDES MODIFIÉS EN C-17 ET C-3 PRÉSENTANT UNE ACTIVITÉ INHIBITRICE DE LA MATURATION DU VIH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012106190A1

  公开（公告）日：2012-08-09

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III. These compounds are useful for the treatment of HIV and AIDS.

  具有药物和生物影响特性的化合物，其药物组合物和使用方法已列出。具体来说，提供了具有独特抗病毒活性的C-17和C-3修饰三萜类化合物，作为HIV成熟抑制剂，如公式I、II和III所代表的化合物。这些化合物对治疗HIV和艾滋病有用。
• Diphenylmethylene piperidines
  申请人：Warner-Lambert Company

  公开号：US04540780A1

  公开（公告）日：1985-09-10

  Novel chemical compounds which are diphenylmethylene piperidine compounds are provided, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds have both anticholinergic and antidopaminergic properties, and are useful as antiemetic, antihistamine, pulmonary, antiallergy, and antispasmodic agents.

  提供了一种新型的化学化合物，这些化合物是二苯甲烯哌啶类化合物，以及生产这些化合物的方法，包括含有这些化合物的药物组合物，以及使用这些化合物的治疗方法。这些化合物具有抗胆碱能和抗多巴胺能性质，并且可用作抗恶心、抗组胺、肺部、抗过敏和抗痉挛剂。
• DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS
  申请人：VENNERSTROM JONATHAN L.

  公开号：US20080125411A1

  公开（公告）日：2008-05-29

  A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.

  本发明提供了一种治疗疟疾、血吸虫病和癌症的方法和手段，使用螺环或二螺环1,2,4-三噁烷酮。首选的1,2,4-三噁烷酮包括一个螺环戊烷基团在三噁烷基团的一侧，以及一个螺环己基在三噁烷基团的另一侧。与青蒿素半合成衍生物相比，本发明的化合物结构简单，易于合成，无毒，并且对疟原虫具有强效作用。该发明的化合物意外地提供了一次性治愈疟疾的方法，以及对其的预防活性。该化合物也对血吸虫病和癌症具有活性。
• C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY
  申请人：REGUEIRO-REN ALICIA

  公开号：US20130035318A1

  公开（公告）日：2013-02-07

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.

  本文介绍了具有药物和生物影响性质的化合物、它们的制药组合物和使用方法。特别地，提供了具有独特的抗病毒活性的C-17和C-3修饰三萜类化合物，作为HIV成熟抑制剂，如公式I、II和III所表示的化合物：这些化合物对于治疗HIV和艾滋病是有用的。