4-fluoro-N-[[(5R)-3-(3-fluoro-4-thiomorpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide | 1430414-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 4-fluoro-N-[[(5R)-3-(3-fluoro-4-thiomorpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide
• 英文别名: 4-fluoro-N-[[(5R)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]benzenesulfonamide
• CAS: 1430414-28-0
• 化学式: C₂₀H₂₁F₂N₃O₄S₂
• 分子量: 469.533
• InChiKey: RYMHIIKUQRCDJR-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-氟苯磺酰氯 、 (S)-5-(aminomethyl)-3-(3-fluoro-4-thiomorpholinophenyl)oxazolidin-2-one 在 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 以56%的产率得到4-fluoro-N-[[(5R)-3-(3-fluoro-4-thiomorpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide
  参考文献：
  名称：

  Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents

  摘要：

  A number of linezolid-like oxazolidino-sulfonamides (7a-y and 8a-b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0-6.0 mu g/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 mu g/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.034

文献信息

• Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents
  作者：Ahmed Kamal、P. Swapna、Rajesh V.C.R.N.C. Shetti、Anver Basha Shaik、M.P. Narasimha Rao、Soma Gupta

  DOI：10.1016/j.ejmech.2013.01.034

  日期：2013.4

  A number of linezolid-like oxazolidino-sulfonamides (7a-y and 8a-b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0-6.0 mu g/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 mu g/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. (C) 2013 Elsevier Masson SAS. All rights reserved.