2-(diphenylphosphano)phenyl 4-chlorobutanoate-borane | 1260029-00-2

• 英文名称: 2-(diphenylphosphano)phenyl 4-chlorobutanoate-borane
• CAS: 1260029-00-2
• 化学式: C₂₂H₂₃BClO₂P
• 分子量: 396.661
• InChiKey: VQFTUEVMJGHMSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  2-(diphenylphosphano)phenyl 4-chlorobutanoate-borane 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 72.0h， 以54%的产率得到2-(diphenylphosphano)phenyl 4-iodobutanoate-borane
  参考文献：
  名称：

  The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

  摘要：

  The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.134
• 作为产物：
  描述：

  o-hydroxyphenyl-diphenylphosphane-borane 、 4-氯丁酰氯 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以96%的产率得到2-(diphenylphosphano)phenyl 4-chlorobutanoate-borane
  参考文献：
  名称：

  The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

  摘要：

  The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.134