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    首页 分子通 N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)isoxazolo[5,4-b]pyridine-4-carboxamide

    N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)isoxazolo[5,4-b]pyridine-4-carboxamide | 1431709-96-4

    分子结构分类

    有机化合物 - 有机杂环化合物 - 异恶唑并吡啶类
    中文名称
    ——
    中文别名
    ——
    英文名称
    N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)isoxazolo[5,4-b]pyridine-4-carboxamide
    英文别名
    N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-(oxan-4-yl)-[1,2]oxazolo[5,4-b]pyridine-4-carboxamide
    N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)isoxazolo[5,4-b]pyridine-4-carboxamide化学式
    CAS
    1431709-96-4
    化学式
    C26H27N5O5
    mdl
    ——
    分子量
    489.531
    InChiKey
    ZCKYQTCTSYYDJG-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      2.4
    • 重原子数：
      36
    • 可旋转键数：
      7
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.35
    • 拓扑面积：
      122
    • 氢给体数：
      1
    • 氢受体数：
      9

    文献信息

    • [EN] ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS D'OREXINE DE TYPE ISOXAZOLOPYRIDINE
      申请人：MERCK SHARP & DOHME
      公开号：WO2013062858A1
      公开（公告）日：2013-05-02
      The present invention is directed to isoxazolopyndine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the isoxazolopyndine compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
      本发明涉及对于促进素受体的拮抗剂——异噁唑吡啶类化合物。本发明还涉及使用本文所述的异噁唑吡啶类化合物在神经系统和精神障碍和疾病的治疗或预防中，其中促进素受体参与其中。本发明还涉及包含这些化合物的制药组合物。本发明还涉及使用这些制药组合物在预防或治疗促进素受体参与的这些疾病中。
    • ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS
      申请人：MERCK SHARP & DOHME CORP.
      公开号：US20150038502A1
      公开（公告）日：2015-02-05
      The present invention is directed to isoxazolopyndine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the isoxazolopyndine compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
      本发明涉及对促进醒觉的受体进行拮抗的异噁唑吡啶化合物。本发明还涉及使用本文所述的异噁唑吡啶化合物在预防或治疗涉及促进醒觉的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进醒觉的疾病中的用途。
    • US9242995B2
      申请人：——
      公开号：US9242995B2
      公开（公告）日：2016-01-26
    查看更多

    同类化合物

    苯胺,4-肼基-3-甲氧基-N-苯基- 环丁[b][1,2]恶唑并[4,5-e]吡啶 异恶唑并[5,4-B]吡啶-3-胺 异噁唑并[5,4-c]吡啶-3-胺 异噁唑并[5,4-b]吡啶-3-醇 异噁唑并[4,5-b]吡啶-3-胺 异噁唑并[4,5-b]吡啶-3(2H)-酮 [1,2]恶唑并[5,4-e]吲嗪 9-氧杂-3-氮杂三环[5.2.1.03,8]癸-1,5,7-三烯 7H-[1,3]恶唑并[3,2-a]环氧乙烷并[d]吡啶 7-羟基-3-甲基[1,2]恶唑并[4,5-b]吡啶-5(4H)-酮 6-甲氧基-3-甲基[1,2]恶唑并[4,5-c]吡啶 6-(叔丁基)-3-甲基异噁唑并[5,4-B]吡啶-4-羧酸 5-肼基-3-甲基[1,2]恶唑并[4,5-b]吡啶 5-乙基-3-甲基[1,2]恶唑并[5,4-b]吡啶 5-乙基-3-甲基[1,2]恶唑并[4,5-b]吡啶 5,7-二氯-3-甲基异噁唑并[4,5-B]吡啶 4-甲氧基-3-甲基[1,2]恶唑并[5,4-b]吡啶 4-氧杂-7-氮杂三环[4.3.1.03,7]癸-1(9),2,5-三烯 4,6-二甲基异噁唑(5,4-B)吡啶-3-胺 3-甲基异噁唑并[5,4-b]吡啶 3-甲基[1,2]恶唑并[5,4-b]吡啶-5-甲酰氯 3-甲基[1,2]恶唑并[4,5-b]吡啶2-氧化物 3-甲基-6-噻吩-2-基异恶唑并[5,4-b]吡啶-4-羧酸 3-甲基-5H-异恶唑并[4,5-c]吡啶-4-酮 3-溴异噁唑并[5,4-B]吡啶 3-氨基异恶唑[4,5-C]并吡啶 3-(溴甲基)异噁唑并[5,4-B]吡啶 3-(1,3-苯并二恶唑-5-基)-N-[(1S)-1-苯乙基]-异唑并[5,4-c]吡啶-5-胺 3,6-二甲基[1,2]恶唑并[5,4-b]吡啶-4-醇 3,6-二甲基[1,2]恶唑并[5,4-b]吡啶 3,4-二甲基[1,2]恶唑并[5,4-b]吡啶-6(7H)-酮 2H-环戊二烯并[d]异噻唑并[5,4-b]吡啶(9CI) 2H-环戊二烯并[b][1,2]恶唑并[4,5-e]吡啶 2H-[1,2]恶唑并[5,4-b]吡咯并[3,4-D]吡啶 2-氯-N-异噁唑并[5,4-B]吡啶-3-基乙酰胺 1H-咪唑,1-丁基-2,5-二氢-2-(1-甲基乙基)- Methyl 3-cyclohexyloxy-6-cyclopropyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylate Prop-2-ynyl 6-cyclopropyl-3-methyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylate (S)-ethyl 2-(2-((3,5-dimethylisoxazol-4-yl)(hydroxy)methyl)furo[3,2-b]pyridin-5-yl)acetate (6-Chloropyridin-3-yl)methyl 6-cyclopropyl-3-methyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylate 5-Furyl-7-methyl-furo<2,3-c>pyridin 3-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]isoxazolo[4,5-e]pyridine 6-bromoisoxazolo[4,5-b]pyridin-3-amine 7-((S)-2-hydroxy-1-methyl-ethylamino)-[1,6]naphthyridine-2-carboxylic acid [(S)-(3-fluoro-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide 7-bromo-3-(4-chloro-phenyl)-4-hydroxy-isoxazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 3-(4-methoxy-phenyl)-4-hydroxy-isoxazolo[5,4-c]pyridine-5-carboxylic acid ethyl ester 6-Cyclopropyl-3-methoxy-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid Methanone, (3-amino-1-piperidinyl)[6-(2,5-dimethyl-3-thienyl)-3-methylisoxazolo[5,4-b]pyridin-4-yl]- 9-(4-Chloro-phenyl)-3-(3,4-dichloro-phenyl)-5-methyl-isoxazolo[4,5-e][1,2,4]triazolo[4,3-c]pyrimidine

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