3-Methyl-2-[3-(3-methyl-1,3-benzothiazol-3-ium-2-yl)-2-phenylprop-2-enylidene]-1,3-benzoxazole | 855123-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 英文名称: 3-Methyl-2-[3-(3-methyl-1,3-benzothiazol-3-ium-2-yl)-2-phenylprop-2-enylidene]-1,3-benzoxazole
• CAS: 855123-86-3
• 化学式: C₂₅H₂₁N₂OS
• 分子量: 397.521
• InChiKey: XMKWLOWLGABFSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Methine-substituted cyanine dye compounds
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10005908B2

  公开（公告）日：2018-06-26

  Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

  具有取代的甲基的氰基染料化合物，可作为核酸染色剂，特别是用于 RNA 的荧光染色，包括具有以下式子的化合物 其中 R1 是 C1-C6 烷基、磺酰基、羧基烷基或 C1-C6 烷氧基；每个 R2 独立地选自 H、C1-C6 烷基、C1-C6 烷氧基、熔融苯并、三氟甲基、氨基、磺酰基、羧基和卤素组成的组，可选择进一步取代；R3、R4 和 R5 中至少一个是任选被烷基、氨基、氨基烷基、羧基、硝基或卤素取代的烷基、芳基、杂芳基、环状或杂环分子；其余 R3、R4 或 R5 为氢；X 为 S、O 或 Se；D 为取代或未取代的吡啶鎓、喹啉鎓或苯并唑鎓分子。
• METHINE-SUBSTITUTED CYANINE DYE COMPOUNDS
  申请人：DALLWIG Jason Alfred

  公开号：US20100317543A1

  公开（公告）日：2010-12-16

  Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R 1 is a C 1 -C 6 alkyl, sulfoalkyl, carboxyalkyl or C 1 -C 6 alkoxy; each R 2 is independently selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R 3 , R 4 , and R 5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R 3 , R 4 or R 5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
• Methine-Substituted Cyanine Dye Compounds
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20130252842A1

  公开（公告）日：2013-09-26

  Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R 1 is a C 1 -C 6 alkyl, sulfoalkyl, carboxyalkyl or C 1 -C 6 alkoxy; each R 2 is independently selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R 3 , R 4 , and R 5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R 3 , R 4 or R 5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
• US7776529B2
  申请人：——

  公开号：US7776529B2

  公开（公告）日：2010-08-17
• US8470529B2
  申请人：——

  公开号：US8470529B2

  公开（公告）日：2013-06-25