5-(6,7-dihydro-5H-thieno[3,2-b]pyran-7-ylmethyl)-1H-imidazole | 1114824-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡喃类
• 英文名称: 5-(6,7-dihydro-5H-thieno[3,2-b]pyran-7-ylmethyl)-1H-imidazole
• CAS: 1114824-49-5
• 化学式: C₁₁H₁₂N₂OS
• 分子量: 220.295
• InChiKey: VLXFJHXEALADSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ALPHA2C ADRENORECEPTOR AGONISTS<br/>[FR] AGONISTES DES RÉCEPTEURS ADRÉNERGIQUES ALPHA2C
  申请人：SCHERING CORP

  公开号：WO2009020578A1

  公开（公告）日：2009-02-12

  In its many embodiments, the present invention provides a novel class of compounds of formula I that are useful as inhibitors of alpha2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the alpha2C adrenergic receptors using such compounds or pharmaceutical compositions. wherein: J is: Z is -[C(RC)(RC)]X; A is a 5-membered heteroaryl, heterocyclyl or heterocyclenyl ring containing 1- 3 heteroatoms, preferably selected from the group consisting of -O-, -S- and -N-, and is optionally substituted with at least one R5 and/or 1 or 2 (=O) (carbonyl) groups; and the rest of the variables are as specified in claim 1.

  在其多种实施方式中，本发明提供了一类新型的化合物，其化学式为I，这些化合物可用作α2C肾上腺素受体激动剂的抑制剂，包括制备这类化合物的方法，含有一种或多种这类化合物的药物组合物，制备包含一种或多种这类化合物的药物配方的方法，以及使用这类化合物或药物组合物治疗、预防、抑制或改善与α2C肾上腺素受体相关的一种或多种疾病的方法。其中：J为：Z为-[C(RC)(RC)]X；A为含有1-3个杂原子的5元杂芳基、杂环基或杂环烯基环，优选选自-O-、-S-和-N-的群，且可选择地取代至少一个R5和/或1或2(=O)(酰基)基团；其余变量如权利要求1所述。
• Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists
  申请人：Allergan, Inc.

  公开号：US10251865B2

  公开（公告）日：2019-04-09

  Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha-2 receptor agonist.

  本文公开了一种通过施用α-2 受体激动剂来上调调节性 T 细胞并治疗可从这种上调中获益的疾病的方法。
• METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS
  申请人：Allergan, Inc.

  公开号：US20140066483A1

  公开（公告）日：2014-03-06

  Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.
• US8575207B2
  申请人：——

  公开号：US8575207B2

  公开（公告）日：2013-11-05
• US9289420B2
  申请人：——

  公开号：US9289420B2

  公开（公告）日：2016-03-22