(4aR,5aR,8aR,8bS)-3-Benzyl-2-chloro-7,7-dimethyl-hexahydro-[1,3]dioxolo[4,5]furo[2,3-e][1,3,2]oxazaphosphinine 2-oxide | 196201-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: (4aR,5aR,8aR,8bS)-3-Benzyl-2-chloro-7,7-dimethyl-hexahydro-[1,3]dioxolo[4,5]furo[2,3-e][1,3,2]oxazaphosphinine 2-oxide
• CAS: 196201-89-5
• 化学式: C₁₅H₁₉ClNO₅P
• 分子量: 359.746
• InChiKey: JLFXCZICQCUEBE-JPXPYNLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  57.23
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  二乙胺 、 (4aR,5aR,8aR,8bS)-3-Benzyl-2-chloro-7,7-dimethyl-hexahydro-[1,3]dioxolo[4,5]furo[2,3-e][1,3,2]oxazaphosphinine 2-oxide 以 四氯化碳 为溶剂， 反应 6.0h， 以43%的产率得到((4aR,5aR,8aR,8bS)-3-Benzyl-7,7-dimethyl-2-oxo-hexahydro-2λ⁵-[1,3]dioxolo[4,5]furo[2,3-e][1,3,2]oxazaphosphinin-2-yl)-diethyl-amine
  参考文献：
  名称：

  Preparation of Novel Cyclophosphamides Derivatives of Sugars

  摘要：

  Novel cyclophosphamide derivatives bearing a sugar structure were prepared by the treatment of the amino sugars from D-glucose and D-xylose with bis-(2-chloroethyl)aminophosphoric dichloride as well as with phosphoryl chloride and nucleophiles.

  DOI：

  10.3987/com-92-6211
• 作为产物：
  描述：

  5-(benzylamino)-5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose 在 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以44%的产率得到(4aR,5aR,8aR,8bS)-3-Benzyl-2-chloro-7,7-dimethyl-hexahydro-[1,3]dioxolo[4,5]furo[2,3-e][1,3,2]oxazaphosphinine 2-oxide
  参考文献：
  名称：

  Preparation of Novel Cyclophosphamides Derivatives of Sugars

  摘要：

  Novel cyclophosphamide derivatives bearing a sugar structure were prepared by the treatment of the amino sugars from D-glucose and D-xylose with bis-(2-chloroethyl)aminophosphoric dichloride as well as with phosphoryl chloride and nucleophiles.

  DOI：

  10.3987/com-92-6211