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    热门化合物HOT
    • 喹啉
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    • 谷胱甘肽
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    首页 分子通 14-Ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione

    14-Ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione | 1575474-24-6

    分子结构分类

    有机化合物 - 有机杂环化合物 - 吡喃嘧啶类
    中文名称
    ——
    中文别名
    ——
    英文名称
    14-Ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione
    英文别名
    14-ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione
    14-Ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione化学式
    CAS
    1575474-24-6
    化学式
    C18H18N2O5
    mdl
    ——
    分子量
    342.351
    InChiKey
    AFFJBBMQASNCGK-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      0.9
    • 重原子数：
      25
    • 可旋转键数：
      2
    • 环数：
      4.0
    • sp3杂化的碳原子比例：
      0.33
    • 拓扑面积：
      68.3
    • 氢给体数：
      0
    • 氢受体数：
      5

    反应信息

    • 作为产物：
      描述：
      1,3-二甲基巴比妥酸 、 3-ethoxy-2-(prop-2-yn-1-yloxy)benzaldehyde 以 neat (no solvent) 为溶剂， 反应 1.0h， 以95%的产率得到14-Ethoxy-4,6-dimethyl-8,12-dioxa-4,6-diazatetracyclo[8.8.0.02,7.013,18]octadeca-2(7),9,13(18),14,16-pentaene-3,5-dione
      参考文献：
      名称：
      Highly stereo and chemoselective synthesis of tetra and pentacyclic frameworks using Solid-State Melt Reaction (SSMR)
      摘要：
      Benzopyran fused tetra and pentacyclic frameworks have been synthesized by the domino Knoevenagel hetero Diels-Alder (DKHDA) reaction using various 1,3-diones with O-allylated salicylaldehydes and O-propargylated salicylaldehydes in a solvent and catalyst free condition via Solid-State Melt Reaction (SSMR). The reaction requires only a single step operation thus providing potentially bioactive polycyclic heterocycles in high yields. (C) 2014 Elsevier Ltd. All rights reserved.
      DOI：
      10.1016/j.tetlet.2014.01.126
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    文献信息

    • Highly stereo and chemoselective synthesis of tetra and pentacyclic frameworks using Solid-State Melt Reaction (SSMR)
      作者：Manickam Bakthadoss、Govindan Sivakumar
      DOI：10.1016/j.tetlet.2014.01.126
      日期：2014.3
      Benzopyran fused tetra and pentacyclic frameworks have been synthesized by the domino Knoevenagel hetero Diels-Alder (DKHDA) reaction using various 1,3-diones with O-allylated salicylaldehydes and O-propargylated salicylaldehydes in a solvent and catalyst free condition via Solid-State Melt Reaction (SSMR). The reaction requires only a single step operation thus providing potentially bioactive polycyclic heterocycles in high yields. (C) 2014 Elsevier Ltd. All rights reserved.
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    同类化合物

    乙基7'-氨基-6-氟-2,2',4'-三羰基-1,1',2,2',3',4'-六氢螺[吲哚-3,5'-吡喃并[2,3-d]嘧啶]-6'-羧酸酯 7H-吡喃并[2,3-d]嘧啶-7-酮 7H-吡喃并[2,3-d]嘧啶 7,8-二氢-5H-吡喃并[4,3-D]嘧啶-2-胺 5H-吡喃并[4,3-d]嘧啶 5H-吡喃并[2,3-d]嘧啶 2H-吡喃并[2,3-d]嘧啶-6-甲腈,7-氨基-1,3,4,5-四氢-5-(4-甲氧苯基)-2,4-二羰基- 2,4-二氯-7,8-二氢-5H-吡喃[4,3-d]嘧啶 1H-吡喃并[3,4-d]嘧啶 1H-吡喃并[3,2-d]嘧啶 4-(4-methoxyaniline)-5-(phenyl)-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)-one 4-cyclohexyl-2-phenyl-7,8-dihydro-6H-pyranol[3,2-d]pyrimidine 1,3-Bis(p-tolyl)-5-(2'-hydroxyphenyl)-7-methyl-4-oxo-1,2,3,4-tetrahydro-2-thioxo-5H-pyrano<2,3-d>pyrimidine 7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one 7-amino-2,3,4,5-tetrahydro-5-(3-hydroxyphenyl)-1,3-dimethyl-2,4-dioxo-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile 3-benzyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-isochromeno[3,4-d]pyrimidin-1-ol 7'-amino-1-ethyl-2,4'-dioxo-2'-thioxo-1',2',3',4'-tetrahydrospiro[indoline-3,5'-pyrano[2,3-d] pyrimidine]-6'-carbonitrile 7'-amino-2,4'-dioxo-2'-thioxo-1',2',3',4'-tetrahydro-2H-spiro[acenaphthylene-1,5'-pyrano[2,3-d]pyrimidine]-6'-carbonitrile (3-(((2-(4-(but-2-ynamido)-2-methyl-1H-indol-1-yl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)amino)methyl)phenyl)boronic acid 7-amino-5-(2,3-dimethoxyphenyl)-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile 7'-amino-5-chloro-1',3'-dimethyl-2,2',4'-trioxo-1',2',3',4'-tetrahydrospiro[indoline-3,5'-pyrano[2,3-d]pyrimidine]-6'-carbonitrile 7-amino-5-(4-bromophenyl)-1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile 7-amino-5-(4-methoxyphenyl)-1,3-dimethyl-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]-pyrimidine-6-carbonitrile 7,8-dihydro-5H-pyrano[4,3-d]pyrimidine ethyl 2,8-dimethyl-10-phenyl-10H-pyrano[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine-9-carboxylate ethyl 10-(4-methoxyphenyl)-2,8-dimethyl-10H-pyrano[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine-9-carboxylate ethyl 3-{[3-(4-methoxyphenyl)isoxazol-5-yl]methyl}-2,7-dimethyl-4-oxo-5-(p-tolyl)-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine-6-carboxylate 2-thioxo-2,3,7,8-tetrahydro-1H-pyrano[4.3-d]pyrimidin-4(5H)-one 7-amino-2,4-dioxo-5-(m-tolyl)-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile Ethyl 7-amino-5-(4-hydroxyphenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carboxylate 7-amino-5-(3-chlorophenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile 7-amino-5-(2,4-di-chlorophenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile 7-amino-5-(4-(dimethylamino)phenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile Ethyl 7-amino-5-(3,4-dimethoxyphenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carboxylate 7-amino-5-(3,4-dimethoxyphenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile ethyl-7-amino-5-(3-nitrphenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carboxylate Ethyl 7-amino-5-(4-nitrophenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carboxylate Ethyl 7-amino-5-(4-methylphenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carboxylate 7'-amino-5-chloro-2,2',4'-trioxo-1',2',3',4'-tetrahydrospiro[indoline-3,5'-pyrano[2,3-d]pyrimidine]-6'-carbonitrile 4-tert-butyl-2-phenyl-7,8-dihydro-6H-pyranol[3,2-d]pyrimidine 6-benzamido-2,3-dihydro-5-methyl-1,3-di(p-chlorophenyl)-2-thioxo-4H-pyrano[2,3-d]pyrimidine-4,7(1H)-dione 6-benzamido-2,3-dihydro-5-methyl-1,3-diphenyl-2-thioxo-4H-pyrano[2,3-d]pyrimidine-4,7(1H)-dione 4-phenylhexahydro-1H-pyrano[2,3-d]pyrimidin-2(8aH)-one 4-(4-methoxyphenyl)hexahydro-1H-pyrano[2,3-d]pyrimidin-2(8aH)-one 7-amino-1,3-dimethyl-2,4-dioxo-5-phenyl-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile 7'‑amino‑2,4′‑dioxo‑2′‑thioxo‑1′,2′,3′,4′‑tetrahydrospiro[indoline‑3,5'‑pyrano[2,3‑d]pyrimidine]‑6'‑carbonitrile 7-Amino-5-(1H-indol-3-yl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d] pyrimidine-6-carbonitrile methyl 2-amino-5,7-dioxospiro[1'-methyl-3'H-indol-3',4-4H-5,6,7,8-tetrahydropyrano[2,3-d]pyramidine]-1'H-2'-one-3-carboxylate 7-benzyl-7-methyl-4-phenyl-3,4,7,8-tetrahydro-1H-pyrano[4,3-d]pyrimidine-2,5-dione 7,7-dimethyl-4-phenyl-2-thioxo-1,2,3,4,7,8-hexahydro-pyrano[4,3-d]pyrimidin-5-one

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