4-Pentyl-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one | 28401-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并咪唑类化合物
• 英文名称: 4-Pentyl-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one
• CAS: 28401-02-7
• 化学式: C₁₀H₁₈N₂OS
• 分子量: 214.332
• InChiKey: ZBHNDARKCKTDLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Dimethyl 2-oxo-4-pentylthieno[3,4-d]imidazole-1,3-dicarboxylate 生成 4-Pentyl-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-2-one
  参考文献：
  名称：

  SKLAVOUNOS, CONSTANTINE

  摘要：

  DOI：

文献信息

• MAX BINDERS AS MYC MODULATORS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20170233405A1

  公开（公告）日：2017-08-17

  The present disclosure provides compounds of Formula (I′), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.

  本公开提供了Formula (I′)、Formula (I)、Formula (II)、Formula (II-A)、Formula (III)和Formula (IV)的化合物。本文描述的化合物是MAX结合蛋白和/或Myc、MAd或Mxi1的调节剂（例如，Myc、MAd或Mxi1的抑制剂），可能在治疗与Myc相关的疾病的患者中有用，例如增殖性疾病（例如癌症）。本公开还提供了包括上述化合物的药物组合物和试剂盒，以及使用这些化合物、组合物和试剂盒的方法和用途。
• [EN] UNIVERSAL ABT COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ABT UNIVERSELS ET LEURS UTILISATIONS
  申请人：KLEO PHARMACEUTICALS INC

  公开号：WO2019023501A1

  公开（公告）日：2019-01-31

  Among other things, the present disclosure provides compounds comprising universal antibody binding moieties and targeting moieties. In some embodiments, provided compounds recruit various types of antibodies to diseased cells such as cancer cells, and induce immune activities to kill such cells. Provided technologies are useful for treating various diseases including cancer.

  除其他外，本公开提供了包含通用抗体结合部分和靶向部分的化合物。在某些实施例中，所提供的化合物可以招募各种类型的抗体到疾病细胞，例如癌细胞，并诱导免疫活性以杀死这些细胞。所提供的技术对于治疗各种疾病包括癌症非常有用。
• SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS
  申请人：NOVARTIS AG

  公开号：US20160237116A1

  公开（公告）日：2016-08-18

  The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses.

  本发明涉及使用化学酶微生物转麦芽氨酰转移酶介导的反应，以功能化肽修饰具有赖氨酸残基的蛋白质的方法和试剂，用于位点选择性修饰。这些功能化蛋白质可用于研究或治疗用途。
• Site-specific chemoenzymatic protein modifications
  申请人：Novartis AG

  公开号：US10975120B2

  公开（公告）日：2021-04-13

  The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses.

  本发明涉及利用微生物转谷氨酰胺酶介导的化学酶促反应，用功能化肽对具有赖氨酸残基的蛋白质进行位点选择性修饰的方法和试剂。功能化蛋白质可用于研究或治疗。
• Products comprising corn oil and corn meal obtained from corn
  申请人：Renessen LLC

  公开号：US20020151733A1

  公开（公告）日：2002-10-17

  Methods of manufacturing and processing corn oil and corn meal obtained from whole corn are included in useful products. The corn oil is extracted from the whole corn to form the corn meal. The corn oil generally comprises levels of nutrients not found in commercially available corn oils, since most or all of the corn grain, rather than just the germ, is exposed to the extraction process. The corn grain generally includes the steps of flaking corn grain having a total oil content of from about 3% to about 6% and extracting a corn oil from the flaked corn grain.

  生产和加工玉米油的方法以及从整粒玉米中提取的玉米粉都包含在有用的产品中。玉米油从整粒玉米中提取，形成玉米粉。玉米油通常含有市售玉米油中没有的营养成分，因为大部分或全部玉米粒，而不仅仅是胚芽，都暴露在萃取过程中。玉米粒一般包括以下步骤：将总含油量约为 3% 至 6% 的玉米粒压片，然后从压片的玉米粒中提取玉米油。