磷化锶 | 12504-13-1

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 各种混合金属/非金属
• 中文名称: 磷化锶
• 英文名称: Strontium phosphide
• 英文别名: tristrontium;phosphorus(3-)
• CAS: 12504-13-1；12504-16-4
• 化学式: P2Sr3
• 分子量: 324.8
• InChiKey: ATAJSUOOOWSVGL-UHFFFAOYSA-N

物化性质

• 物理描述：
  Strontium phosphide is a solid which will evolve flammable and toxic gases on contact with water. It is a highly reactive material used as a laboratory reagent and in the manufacture of chemically reactive devices.
• 颜色/状态：
  Solid
• 熔点：
  Decomposes
• 分解：
  When heated to decomposition it emits toxic fumes of /phosphorus oxides/.

计算性质

• 辛醇/水分配系数(LogP)：
  0.58
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 解毒与急救

立即急救：确保已经进行了充分去污。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/磷化氢及相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phosphine and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。必要时进行吸痰。观察呼吸不足的迹象，必要时协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿并视必要进行治疗……监测休克并视必要进行治疗……预见癫痫并视必要进行治疗……对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。/磷化氢及其相关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . /Phosphine and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用带有气囊面罩的负压通气技术可能有益。考虑对肺水肿进行药物治疗...。监测心率和必要时治疗心律失常...。开始静脉输注D5W/SRP：“保持通路开放”，最低流量/。如果出现低血容量的迹象，使用0.9%盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。如果病人在正常血容量下出现低血压，考虑使用血管加压药。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用丙美卡因氢氯化物协助眼部冲洗...。/磷化氢及相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phosphine and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/其他毒性信息/ 一摩尔的铝磷化物、钾磷化物或钠磷化物会迅速与水或湿气反应，最多产生一摩尔的磷化氢气体。一摩尔的锌磷化物、钙磷化物、镁磷化物或锶磷化物会迅速与水或湿气反应，最多产生两摩尔的磷化氢气体。...在缺乏关于标题金属磷化物的特定化学数据的情况下...使用磷化氢作为金属磷化物的替代物被认为是适当的，因为定性的（临床体征）和定量的（磷化氢血 levels）数据表明，磷化氢的水解产物是金属磷化物引起急性毒性的原因。

/OTHER TOXICITY INFORMATION/ One mole of aluminum phosphide, potassium phosphide, or sodium phosphide will react rapidly with water or moisture to produce a maximum of one mole of phosphine gas. One mole of zinc phosphide, calcium phosphide, magnesium phosphide or strontium phosphide will react rapidly with water or moisture to produce a maximum of two moles of phosphine gas. ... In the absence of appropriate chemical-specific data for the title metal phosphides ... the use of phosphine as a surrogate for the metal phosphides is deemed appropriate because qualitative (clinical signs) and quantitative (phosphine blood level) data suggest that the phosphine hydrolysis product is responsible for acute toxicity from metal phosphides.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  4.3