3-bromo-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole | 2649030-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: 3-bromo-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole
• 英文别名: 3-bromo-3aH,4H,6H,6aH-furo[3,4-d][1,2]oxazole；3-bromo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,2]oxazole
• CAS: 2649030-30-6
• 化学式: C₅H₆BrNO₂
• 分子量: 192.012
• InChiKey: DXNUXSIPLOXHTP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-bromo-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 以50 %的产率得到3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazol-3-ol
  参考文献：
  名称：

  [EN] RXFP1 AGONISTS
  [FR] AGONISTES DE RXFP1

  摘要：

  The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

  公开号：

  WO2023077040A1
• 作为产物：
  描述：

  2,5-二氢呋喃 、 1,1-二溴甲醛肟 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以32 %的产率得到3-bromo-3a,4,6,6a-tetrahydrofuro[3,4-d]isoxazole
  参考文献：
  名称：

  [EN] RXFP1 AGONISTS
  [FR] AGONISTES DE RXFP1

  摘要：

  The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

  公开号：

  WO2023077040A1