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    首页 分子通 3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbohydrazide

    3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbohydrazide | 775573-28-9

    分子结构分类

    有机化合物 - 有机杂环化合物 - 咪唑四嗪类
    中文名称
    ——
    中文别名
    ——
    英文名称
    3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbohydrazide
    英文别名
    ——
    3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbohydrazide化学式
    CAS
    775573-28-9
    化学式
    C6H7N7O2
    mdl
    ——
    分子量
    209.17
    InChiKey
    OUVDREHSXNEDPW-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      -1.4
    • 重原子数：
      15
    • 可旋转键数：
      1
    • 环数：
      2.0
    • sp3杂化的碳原子比例：
      0.17
    • 拓扑面积：
      118
    • 氢给体数：
      2
    • 氢受体数：
      6

    文献信息

    • DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER
      申请人：Patil Rameshwar
      公开号：US20140161762A1
      公开（公告）日：2014-06-12
      The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.
    • US8785371B2
      申请人：——
      公开号：US8785371B2
      公开（公告）日：2014-07-22
    • US9320807B2
      申请人：——
      公开号：US9320807B2
      公开（公告）日：2016-04-26
    • US9629919B2
      申请人：——
      公开号：US9629919B2
      公开（公告）日：2017-04-25
    • US9827325B2
      申请人：——
      公开号：US9827325B2
      公开（公告）日：2017-11-28
    查看更多

    同类化合物

    米托唑胺 氰基替莫唑胺 替莫唑胺 N-[4-(2-氟苯甲酰)-1,3-二甲基-1H-吡唑-5-基]-N-甲基苯酰胺 3-(2H3)甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺 3-(2-氯乙基)-N-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺 3-(2-氯乙基)-N,N-二甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺 3-(2-氯乙基)-4-氧代-3H-咪唑并(5,1-d)-1,2,3,5-四嗪-8-羧酸 3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸 8-carbamoyl-3-(2,3-dichloropropyl)-[3H]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one 3-(2-bromoethyl)-8-carbamoyl-[3H]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one 3-(2-((4-fluoro-2-nitrophenyl)(methyl)amino)ethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide 3-(prop-2-ynyl)-8-(4-(thiophen-3-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-(2,4'-bithiazol-2'-yl)-3-methylimidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methylsulfinylmethyl)-8-(4-(thiophen-3-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methoxymethyl)-8-(4-(thiophen-2-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one N,6-dimethyl-4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 3-(methylthiomethyl)-8-(4-(thiophen-3-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methylsulfinylmethyl)-8-(4-(thiophen-2-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-[4-(1,3-Benzodioxol-5-yl)-1,3-thiazol-2-yl]-3-(methoxymethyl)imidazo[5,1-d][1,2,3,5]tetrazin-4-one N-tert-butyl-2-(3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazin-8-yl)thiazole-4-carboxamide 3-methyl-8-(4-(thiophen-3-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-methyl-8-(4-(thiophen-2-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methoxymethyl)-8-(4-(thiophen-3-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methoxymethyl)-8-(4-phenylthiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-(4-tert-butylthiazol-2-yl)-3-propargylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one 3-(methylthiomethyl)-8-(4-(thiophen-2-yl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-(4-(4-bromophenyl)thiazol-2-yl)-3-(prop-2-ynyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methylthiomethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 8-(morpholinosulfonyl)-3-(2,2,2-trifluoroethyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 6-methyl-8-(methylsulfonyl)-3-(prop-2-ynyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-methyl-8-(4-phenylthiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-(4-ethylthiazol-2-yl)-3-methylimidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 8-(methylsulfonyl)-3-(prop-2-ynyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-((methoxymethylthio)methyl)-N-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 8-[4-(4-methylsulfonylphenyl)thiazol-2-yl]-3-propargylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one N-methyl-4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 8-(1-methyl-4-(thiophen-2-yl)-1H-imidazol-2-yl)-3-(prop-2-ynyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-methyl-N-(iso-butyl)-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide N,N-dimethyl-4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 3-(methoxymethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide 8-(4-tert-butylthiazol-2-yl)-3-(methoxymethyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 8-(morpholinosulfonyl)-3-(prop-2-ynyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-(methoxymethyl)-8-(4-(4-(methylsulfonyl)phenyl)thiazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one 3-methyl-8-(1-methyl-1H-benzo[d]imidazol-2-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one N,6-dimethyl-3-(methylsulfinylmethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide N-methyl-4-oxo-3-((2,2,2-trifluoroethoxy)methyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-sulfonamide

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