1-(2-(3-(3-amino-1-hydroxypropyl)phenyl)ethynyl)cyclooctanol | 1098105-45-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(2-(3-(3-amino-1-hydroxypropyl)phenyl)ethynyl)cyclooctanol
• 英文别名: 1-[2-[3-(3-Amino-1-hydroxypropyl)phenyl]ethynyl]cyclooctan-1-ol
• CAS: 1098105-45-3
• 化学式: C₁₉H₂₇NO₂
• 分子量: 301.429
• InChiKey: GSJWINHUHFCXLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
  申请人：Scott Ian Leslie

  公开号：US20090062353A1

  公开（公告）日：2009-03-05

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物，其药物组成物及使用该化合物和组成物治疗眼科疾病和疾患的方法，例如老年性黄斑变性和斯塔格特病。
• Alkynyl Phenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Scott Ian Leslie

  公开号：US20120004269A1

  公开（公告）日：2012-01-05

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物、其制药组合物以及使用该化合物和组合物治疗眼科疾病和障碍的方法，例如老年性黄斑变性和Stargardt病。
• ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian Leslie

  公开号：US20130018077A1

  公开（公告）日：2013-01-17

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物、其制药组合物以及使用该化合物和组合物治疗眼科疾病和疾病的方法，例如老年性黄斑变性和Stargardt病。
• US8299307B2
  申请人：——

  公开号：US8299307B2

  公开（公告）日：2012-10-30
• US8389771B2
  申请人：——

  公开号：US8389771B2

  公开（公告）日：2013-03-05