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    首页 分子通 1-(3,5-dimethyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanone

    1-(3,5-dimethyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanone | 1170668-81-1

    分子结构分类

    有机化合物 - 有机杂环化合物 - 三唑并噻唑类
    中文名称
    ——
    中文别名
    ——
    英文名称
    1-(3,5-dimethyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanone
    英文别名
    1-(3,5-Dimethyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanone
    1-(3,5-dimethyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanone化学式
    CAS
    1170668-81-1
    化学式
    C8H9N3OS
    mdl
    ——
    分子量
    195.245
    InChiKey
    HSWUIQWZHKAKKK-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      2.1
    • 重原子数：
      13
    • 可旋转键数：
      1
    • 环数：
      2.0
    • sp3杂化的碳原子比例：
      0.38
    • 拓扑面积：
      75.5
    • 氢给体数：
      0
    • 氢受体数：
      4

    文献信息

    • [EN] USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS<br/>[FR] UTILISATION DE THIAZOLOIMIDAZOLES, DE THIAZOLOTÉTRAZOLES ET DE THIAZOLOTRIAZOLES COMME ANTAGONISTES DE MGLUR5
      申请人：GLAXO GROUP LTD
      公开号：WO2009087220A1
      公开（公告）日：2009-07-16
      The invention relates to the use of thiazolotriazole, thiazoloimidazole and thiazolotetrazole derivatives of formula (I) in treating diseases and conditions for which antagonism of the mGluR5 receptor is beneficial, in particular substance related disorders. The invention also relates to certain novel derivatives. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
      该发明涉及在治疗对mGluR5受体拮抗有益的疾病和症状，特别是物质相关障碍中使用式(I)的噻唑三唑，噻唑咪唑和噻唑四唑衍生物。该发明还涉及某些新颖的衍生物。此外，该发明涉及含有这些衍生物的组合物以及它们的制备方法。
    查看更多

    同类化合物

    5-(4-甲基苯基)噻唑并[2,3-c]-1,2,4-三唑-3(2H)-硫酮 5-(4-氯苯基)-噻唑并[2,3-c]-1,2,4-三唑-3(2H)-硫酮 1-(6-甲基噻唑并[3,2-B][1,2,4]三唑-5-基)乙酮 1-(6-甲基[1,3]噻唑并[3,2-B] [1,2,4]三唑-5-基)乙醇 (E)-butyl 3-(6-methylthiazolo[3,2-b][1,2,4]triazol-5-yl)acrylate (E)-6-methyl-5-styrylthiazolo[3,2-b][1,2,4]triazole Dimethyl-carbamic acid 6-methyl-thiazolo[3,2-b][1,2,4]triazol-2-yl ester 1-(6-methyl-2-(thiophen-2-yl)thiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one (+/-)-1-[6-methyl-2-(2-thienyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl]ethanol 6-(4-methoxyphenyl)-5-pyrimidin-5-yl-thiazolo[3,2-b][1,2,4]triazole 6-methyl-5-(pyrimidin-5-yl)thiazolo[3,2-b][1,2,4]triazole 6-(p-tolyl)-5-pyrimidin-5-yl-thiazolo[3,2-b][1,2,4]triazole (+/-)-1-(3-bromo-5-methyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanol 3-acethoxymethyl-7-acetyl-6-methyl-5-(2-methyl-4-thiazolyl)pyrrolo<2,1-b>thiazole 1-(6-methylthiazolo[3,2-b][1,2,4]triazol-5-yl)-ethan-1-one oxime 6-methyl-5-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazole 1-(5-Phenyl-thiazolo[2,3-c][1,2,4]triazol-3-yl)-ethanone; hydrochloride (E)-N-tert-butyl-3-(6-methylthiazolo[3,2-b][1,2,4]triazol-5-yl)acrylamide (+/-)-1-(5-methyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethanol 2-Ethyl-5-p-chlorophenylthiazolo<3,2-b>-s-triazole 4-Imino-6-phenyl-4H-thiazolo[2,3-c][1,2,4]triazine-3-carbonitrile Isopropyl-phosphoramidic acid ethyl ester 6-methyl-thiazolo[3,2-b][1,2,4]triazol-2-yl ester 2-Ethyl-5-phenylthiazolo<3,2-b>-s-triazole 2-(6-methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)-2-propanol Dimethyl-phosphinothioic acid O-(6-methyl-thiazolo[3,2-b][1,2,4]triazol-2-yl) ester 2-Hydroxy-6-methyl-thiazolo[3,2-b][1,2,4]triazole-5-carboxylic acid ethyl ester 6-(2-Furanylmethylene)-3-methylthiazolo[2,3-c]-1,2,4-triazol-5(6H)-one 3-Methyl-6-methoxy-1,2,4-triazolo-(2,3-b)-thiazol Thiazolo[2,3-c]-1,2,4-triazole-3-methanamine, 5-(3-fluoro-4-methoxyphenyl)-I+/--methyl- 2-[(4-methoxyphenyl)methyl]-6-methylthiazolo[3,2-b]-1,2,4-triazole-5-carboxylic acid ethyl ester 2-[(4-methoxyphenyl)ethyl]thiazolo[3,2-b]-1,2,4-triazole-6-acetic acid ethyl ester Thiophosphoric acid O-(5-bromo-6-ethyl-thiazolo[3,2-b][1,2,4]triazol-2-yl) ester O',O''-diethyl ester 3-(1-(5,7-diisopropyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylmethyl)-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-5-phenyl-thiophene-2-carboxylic acid (E)-6-(4-N,N-dimethylaminobenzylidene)-2-benzylthiazolo[3,2-b][1,2,4]triazol-5(6H)-one 2-[(4-methoxyphenyl)methyl]thiazolo[3,2-b]-1,2,4-triazole-6-acetic acid ethyl ester 5-D-6-phenylthiazolo[3,2-b][1,2,4]triazole 2-[(4-methoxyphenyl)ethyl]-6-methylthiazolo[3,2-b]-1,2,4-triazole-5-carboxylic acid ethyl ester 5,6-diphenylthiazolo[3,2-b]-1,2,4-triazole 1-(4-fluorobenzyl)-4-(4-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)thiazol-2-yl)-1H-1,2,4-triazol-5(4H)-one (E)-6-methyl-5-(4-methylstyryl)thiazolo[3,2-b][1,2,4]triazole ethyl 1-(2-fluorobenzyl)-3-(thiazol-2-yl)-1H-1,2,4-triazole-5-carboxylate 6-benzoylamino-2-benzyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazolium betaine 2-(1-ethyl-1H-pyrazol-4-yl)-5-iodo-imidazo[2,1-b][1,3,4]thiadiazole 2-Hydroxy-6-methyl-thiazolo[3,2-b][1,2,4]triazole-5-carboxylic acid methyl ester

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