2-(2-(2-ferrocenylamidoethoxy)ethoxy)acetic acid | 1610606-70-6

• 英文名称: 2-(2-(2-ferrocenylamidoethoxy)ethoxy)acetic acid
• CAS: 1610606-70-6
• 化学式: C₁₇H₂₁FeNO₅
• 分子量: 375.204
• InChiKey: DYRTVQIAQDLDEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 2-(2-(2-ferrocenylamidoethoxy)ethoxy)acetic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 乙腈 为溶剂， 以33%的产率得到2-(2-(2-ferrocenylamidoethoxy)ethoxy)acetic acid succinimidyl ester
  参考文献：
  名称：

  Preparation of ferrocene-functionalized gold nanoparticles by primer extension reaction on the particle surface

  摘要：

  DNA molecules possessing multiple ferrocene (Fc) molecules as a redox active probe were prepared by the primer extension (PEX) reaction using a 2'-deoxyuridine-5'-triphosphate derivative in which Fc was connected to the C5-position of the uridine by a diethylene glycol linker. Gold nanoparticles (AuNP) covered with DNA possessing the Fc molecules were prepared by the PEX reaction on the surface. The AuNP-FcDNA conjugates exhibit a detectable electrochemical signal due to the Fc molecules. Possible application of the PEX reaction on AuNP is demonstrated for the detection of a single nucleotide mutation in the target DNA. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.04.062
• 作为产物：
  描述：

  N-(2-(2-hydroxyethoxy)ethyl)ferrocenyl amide 、 溴乙酸 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以64%的产率得到2-(2-(2-ferrocenylamidoethoxy)ethoxy)acetic acid
  参考文献：
  名称：

  Preparation of ferrocene-functionalized gold nanoparticles by primer extension reaction on the particle surface

  摘要：

  DNA molecules possessing multiple ferrocene (Fc) molecules as a redox active probe were prepared by the primer extension (PEX) reaction using a 2'-deoxyuridine-5'-triphosphate derivative in which Fc was connected to the C5-position of the uridine by a diethylene glycol linker. Gold nanoparticles (AuNP) covered with DNA possessing the Fc molecules were prepared by the PEX reaction on the surface. The AuNP-FcDNA conjugates exhibit a detectable electrochemical signal due to the Fc molecules. Possible application of the PEX reaction on AuNP is demonstrated for the detection of a single nucleotide mutation in the target DNA. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.04.062