1-(4-chlorophenyl)-3-methoxy-1-propanone | 117252-06-9

• 英文名称: 1-(4-chlorophenyl)-3-methoxy-1-propanone
• 英文别名: 1-(4-Chlorophenyl)-3-methoxypropan-1-one
• CAS: 117252-06-9
• 化学式: C₁₀H₁₁ClO₂
• 分子量: 198.649
• InChiKey: YOROVIYKKWQZCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-三甲基硅基-1,3-二噻吩 、 1-(4-chlorophenyl)-3-methoxy-1-propanone 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

  摘要：

  Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.112
• 作为产物：
  描述：

  对氯苯乙酮 在 sodium carbonate 、 三氟乙酸 、 diisopropylammonium trifluoroacetate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成 1-(4-chlorophenyl)-3-methoxy-1-propanone
  参考文献：
  名称：

  Oxa-Michael addition promoted by the aqueous sodium carbonate

  摘要：

  An efficient Michael addition of alcohols to activated alkenes promoted by sodium carbonate with water as reaction medium has been developed. The reaction provides a general, economical and environmentally friendly approach for the synthesis of beta-alkoxycarbonyl compounds. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.019