[(η(5)-C5H5)Fe(CO)(PPh3)CO-3-pyridyl] | 135015-39-3

• 英文名称: [(η(5)-C5H5)Fe(CO)(PPh3)CO-3-pyridyl]
• CAS: 135015-39-3
• 化学式: C₃₀H₂₄FeNO₂P
• 分子量: 517.347
• InChiKey: UHXIQEFDYZIZMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [(η(5)-C5H5)Fe(CO)(PPh3)CO-3-pyridyl] 、 苯基锂 、 氯甲酸甲酯 以 四氢呋喃 为溶剂， 以90%的产率得到(Fe-RS,4-SR)[(η(5)-C5H5)Fe(CO)(PPh3)CO-3-(N-methoxycarbonyl-4-phenyl-1,4-dihydropyridine)]
  参考文献：
  名称：

  Application of the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] to the stereoselective formation of 4-substituted-1,4-dihydronicotinoyl complexes

  摘要：

  In solution regio- and stereoselective additions of nucleophiles to (RS)-[(eta(5)-C5H5)Fe(CO)(PPh(3))CO-3-pyridyl] (1) occur at C-4 to give the corresponding nitrogen-stabilised anions. Subsequent quenching of these anions by a proton, a chloroformate or dimethyl sulfate gives the corresponding 1,4-dihydropyridine complexes as single diastereoisomers. The predicted stereochemical course of the nucleophilic additions is confirmed by a single crystal X-ray structure determination of (Fe-RS,4-RS)-[(eta(5)-C5H5)Fe(CO)(PPh(3))CO-3-(N-methoxycarbonyl-4-methyl-1,4-dihydropyridyl)].

  DOI：

  10.1016/s0020-1693(96)05279-6
• 作为产物：
  描述：

  [(η(5)-C5H5)Fe(CO)2CO-3-pyridyl] 、 三苯基膦 以 环己烷 为溶剂， 以81%的产率得到[(η(5)-C5H5)Fe(CO)(PPh3)CO-3-pyridyl]
  参考文献：
  名称：

  Application of the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] to the stereoselective formation of 4-substituted-1,4-dihydronicotinoyl complexes

  摘要：

  In solution regio- and stereoselective additions of nucleophiles to (RS)-[(eta(5)-C5H5)Fe(CO)(PPh(3))CO-3-pyridyl] (1) occur at C-4 to give the corresponding nitrogen-stabilised anions. Subsequent quenching of these anions by a proton, a chloroformate or dimethyl sulfate gives the corresponding 1,4-dihydropyridine complexes as single diastereoisomers. The predicted stereochemical course of the nucleophilic additions is confirmed by a single crystal X-ray structure determination of (Fe-RS,4-RS)-[(eta(5)-C5H5)Fe(CO)(PPh(3))CO-3-(N-methoxycarbonyl-4-methyl-1,4-dihydropyridyl)].

  DOI：

  10.1016/s0020-1693(96)05279-6