2-Methylidene-2,3-dihydro-1,3-benzoxazole | 57114-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 英文名称: 2-Methylidene-2,3-dihydro-1,3-benzoxazole
• 英文别名: 2-methylidene-3H-1,3-benzoxazole
• CAS: 57114-73-5
• 化学式: C₈H₇NO
• 分子量: 133.15
• InChiKey: XWPHROCGRQOCJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF<br/>[FR] SPIRO-OXAZINES, INDOLINONES ET LEUR PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014184808A1

  公开（公告）日：2014-11-20

  The present invention relates to novel spiro-oxazine analogues of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II Further the invention provides transition- metal free multicomponent reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile,under mild condition leading to formation of desired complex of spiro-oxazine analogues (I) and indolinone analogues (II) in high yield and selectivity.

  本发明涉及式I的新型螺环氧化吲哚类似物和式II的吲哚酮化合物或其位置异构体、对映异构体、衍生物或药用可接受盐。进一步地，本发明提供了一种无需过渡金属的多组分反应（MCR）过程，用于在温和条件下使用芳炔前体、N-取代异色满和N-杂芳族化合物作为亲核试剂来制备式I和II的化合物，从而高收率和选择性地形成所需的螺环氧化吲哚类似物（I）和吲哚酮类似物（II）的复杂结构。
• Photochromic compounds
  申请人：——

  公开号：US20030045714A1

  公开（公告）日：2003-03-06

  A photochromic compound suitable for use as a single substance for photochromic tinting of a transparent plastic article so that the tinted article has a neutral gray or brown color in the excited state, is made by fusing at least two non-identical photochromic sections to an aromatic structure. The photochromic sections are selected so that the different absorption wavelengths of the excited photochromic sections give rise to a neutral gray or brown color in the plastic material and are selected from the group consisting of oxazines and pyrans. At least one of the photochromic sections is not an indolino spiropyran. The aromatic structure to which the photochromic sections are fused is selected from the group consisting of benzene, biphenyl, naphthalene, anthracene and phenanthrene. The positions of fusion of the photochromic sections on the aromatic structure are directly adjacent to the oxygen atom of the pyran or the oxygen or nitrogen atom of the oxazine.

  一种光致变色化合物适用于作为单一物质用于透明塑料制品的光致变色涂层，使得涂层的物品在兴奋态下呈中性灰色或棕色。该化合物通过将至少两个非相同的光致变色部分熔合到芳香结构上制成。这些光致变色部分被选择为不同吸收波长的光致变色部分，以在塑料材料中产生中性灰色或棕色，并且被选自氧杂环和吡喃类化合物组。至少其中一个光致变色部分不是吲哚螺吡喃。光致变色部分熔合到的芳香结构被选自苯、联苯、萘、蒽和菲。光致变色部分在芳香结构上的熔合位置直接邻接于吡喃的氧原子或氧杂环的氧或氮原子。
• Anthranilic acid derivatives and their use as activators of the hm74a receptor
  申请人：Campbell Matthew

  公开号：US20070191378A1

  公开（公告）日：2007-08-16

  Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.

  本文披露了公式（I）的治疗活性蒽酸衍生物，制备该衍生物的过程，含有该化合物的制药配方以及化合物在治疗中的使用，特别是在治疗HM74A受体欠活化导致疾病或激活该受体将有益的疾病中的使用。
• DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
  申请人：Hatayama Akira

  公开号：US20100087442A1

  公开（公告）日：2010-04-08

  The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).

  本发明涉及式(I)的二酮肼衍生物及其药学上可接受的盐（式中符号与说明书中描述的含义相同）。式(I)化合物具有对半胱氨酸蛋白酶的抑制活性，可用于治疗炎症性疾病、免疫性疾病、缺血性疾病、呼吸系统疾病、循环系统疾病、血液疾病、神经系统疾病、肝胆系统疾病、骨骼或关节疾病、代谢性疾病等。该化合物具有对弹性蛋白酶的抑制活性，也可用于治疗慢性阻塞性肺部疾病（COPD）。
• BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
  申请人：Kawatkar Aarti Sameer

  公开号：US20110059965A1

  公开（公告）日：2011-03-10

  Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:

  具有式(I)的二环衍生物及其组成物可用作离子通道拮抗剂。