Disodium;2,2,4,4,6,6-hexaoxido-1,3,5,2,4,6-trioxatrisilinane;zirconium

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 英文名称: Disodium;2,2,4,4,6,6-hexaoxido-1,3,5,2,4,6-trioxatrisilinane;zirconium
• 英文别名: disodium;2,2,4,4,6,6-hexaoxido-1,3,5,2,4,6-trioxatrisilinane;zirconium
• 化学式: Na2O9Si3Zr-4
• 分子量: 365.45
• InChiKey: ARVUQMBOTBOHPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -14.48
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  166
• 氢给体数：
  0
• 氢受体数：
  9

ADMET

代谢

sodium zirconium silicate is an inorganic compound that is insoluble and not susceptible to enzymatic metabolism. In addition, studies have shown that it is not absorbed systemically. The results of a mass balance study in rats showed that sodium zirconium silicate was recovered in the feces without any signs of systemic absorption. Due to these factors and its insolubility, no in vivo or in vitro studies have been conducted to examine its effects on cytochrome P450 (CYP450) enzymes or transporter activity.

Sodium zirconium cyclosilicate is an inorganic, insoluble compound that is not susceptible to enzymatic metabolism. Additionally, studies have shown it not to be systemically absorbed either. An in vivo mass balance study in rats showed that sodium zirconium cyclosilicate was recovered in the feces with no evidence of systemic absorption. Due to these factors and its insolubility, no _in vivo_ or _in vitro_ studies have thus far been performed to examine its effect on cytochrome P450 (CYP450) enzymes or transporter activity.

来源:DrugBank

毒理性

• 毒性总结

过量服用锆硅酸钠可能导致低钾血症。

Overdose with sodium zirconium cyclosilicate could lead to hypokalemia.

来源:DrugBank

吸收、分配和排泄

• 吸收

环硅酸锆钠是一种无机、不溶于水的化合物，不易受酶代谢的影响。此外，研究还表明它也不会被系统吸收。在大鼠体内的质量平衡研究中，环硅酸锆钠在粪便中被回收，没有证据表明有系统性吸收。

Sodium zirconium cyclosilicate is an inorganic, insoluble compound that is not susceptible to enzymatic metabolism. Additionally, studies have shown it not to be systemically absorbed either. An in vivo mass balance study in rats showed that sodium zirconium cyclosilicate was recovered in the feces with no evidence of systemic absorption.

来源:DrugBank

吸收、分配和排泄

• 消除途径

环硅酸锆钠通过粪便排出。

Sodium zirconium cyclosilicate is eliminated in the feces.

来源:DrugBank