(2Z)-3-hexadecyl-2-[(E)-3-(3-hexadecyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole;perchlorate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 英文名称: (2Z)-3-hexadecyl-2-[(E)-3-(3-hexadecyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole;perchlorate
• 化学式: C49H77ClN2O6
• 分子量: 825.6
• InChiKey: KSBJVTKVHPXESV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  10.68
• 重原子数：
  58
• 可旋转键数：
  32
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• MATERIAL COMPRISING A POLYMER CAPABLE OF FORMING A HYDROGEL AND NANOPARTICLES
  申请人：COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

  公开号：EP3103485A1

  公开（公告）日：2016-12-14

  The present invention concerns a material comprising a polymer capable of forming a hydrogel and nanoparticles comprising a solubilising lipid comprising at least one fatty acid glyceride, an amphiphilic lipid, and a co-surfactant comprising at least one poly(ethylene oxide) chain or a chitosan chain, the process for the preparation thereof and the uses thereof.

  本发明涉及一种由能够形成水凝胶的聚合物和纳米颗粒组成的材料，纳米颗粒包含由至少一种脂肪酸甘油酯组成的增溶脂质、两性脂质和由至少一种聚环氧乙烷链或壳聚糖链组成的辅助表面活性剂，还涉及其制备工艺及其用途。
• Method for transfection of nucleic acids into eukaryotic cells in 3D scaffold
  申请人：Commissariat à l'énergie atomique et aux énergies alternatives

  公开号：US10253315B2

  公开（公告）日：2019-04-09

  The present invention concerns a method for in vitro or ex vivo transfection of a nucleic acid into a eukaryotic cell in 3D scaffold by contacting eukaryotic cells in 3D scaffold with a formulation in nanoemulsion form which comprises a continuous aqueous phase and a least one dispersed phase, and which comprises said nucleic acid. The invention further relates to a method of screening implementing said method of transfection, and to 3D scaffold comprising eukaryotic cells and said formulation in nanoemulsion form which comprises a continuous aqueous phase and a least one dispersed phase, and which comprises said nucleic acid.

  本发明涉及一种将核酸体外或体内转染到三维支架中的真核细胞的方法，该方法是将三维支架中的真核细胞与纳米乳液形式的制剂接触，该制剂包括连续的水相和至少一个分散相，并且包含所述核酸。本发明还涉及一种实施所述转染方法的筛选方法，以及包含真核细胞和所述纳米乳液形式制剂的三维支架，所述纳米乳液形式制剂包括连续的水相和至少一个分散相，并且包含所述核酸。
• Porphyrin modified telodendrimers
  申请人：The Regents of the University of California

  公开号：US10238750B2

  公开（公告）日：2019-03-26

  The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

  本发明提供聚合形成纳米载体的两亲性端二聚体，其特征为疏水内核和亲水外表。纳米载体内核可包括两亲官能团，如胆酸或胆酸衍生物，外部可包括支链或线性聚乙二醇段。纳米载体货物（如疏水性药物和其他材料）可通过非共价方式固着在内核中，也可与端二聚体结构单元共价结合。可对端二聚体结构进行定制，以改变装载特性、与生物膜等材料的相互作用以及其他特性。
• High-throughput screening method for the identification of biomarkers, therapeutic targets or therapeutic agents
  申请人：COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

  公开号：US10597700B2

  公开（公告）日：2020-03-24

  The present invention relates to a method for screening a molecule of interest by means of nanoparticles comprising a candidate molecule, a tracer, and a single DNA tag specific to said molecule. The present invention also relates to a method for screening biomarkers of a disease and/or of a phenotype feature, more particularly of a cancer or an infection, by means of said nanoparticles. The invention finally relates to the nanoparticles as such as well as to a library of said nanoparticles.

  本发明涉及一种通过纳米颗粒筛选感兴趣分子的方法，纳米颗粒包括候选分子、示踪剂和与所述分子特异的单个 DNA 标签。本发明还涉及一种通过所述纳米颗粒筛选疾病和/或表型特征（尤其是癌症或感染）生物标记物的方法。最后，本发明还涉及纳米颗粒本身以及纳米颗粒库。
• PORPHYRIN MODIFIED TELODENDRIMERS
  申请人：The Regents of the University of California

  公开号：EP2931290A1

  公开（公告）日：2015-10-21