N,N-dimethyl-4-(5-methyl-2,3-dihydro-1,3-benzoxazol-2-yl)aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 英文名称: N,N-dimethyl-4-(5-methyl-2,3-dihydro-1,3-benzoxazol-2-yl)aniline
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.33
• InChiKey: UXVPRBJABPZLAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Fluorinated 2-arylbenzo heterocyclic compound with high affinity to A beta 946; plaques and containing chiral side chain substituent, and preparation method and usage thereof
  申请人：BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD

  公开号：US20160207910A1

  公开（公告）日：2016-07-21

  A fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R 1 is a 5 or 6-substituent and is F is 19 F or 18 F; R 2 is NHCH 3 or N(CH 3 ) 2 . The compound of the present invention has high affinity to Aβ plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.

  一种含有手性侧链取代基的氟代2-芳基苯并杂环化合物，对Aβ斑块具有高亲和力，其一般化学式（I）如下：其中X为N；Y为S或O；Z为N或CH；R1为5或6-取代基，F为19F或18F；R2为NHCH3或N(CH3)2。本发明的化合物对Aβ斑块具有高亲和力，可用于制备适当的放射性核素标记探针，用于早期诊断阿尔茨海默病。