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    首页 分子通 5,6-Dimethyl-2-(methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole

    5,6-Dimethyl-2-(methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole | 22423-16-1

    分子结构分类

    有机化合物 - 核苷、核苷酸和类似物 - 苯并咪唑核糖核苷和核糖核苷酸
    中文名称
    ——
    中文别名
    ——
    英文名称
    5,6-Dimethyl-2-(methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole
    英文别名
    2-(5,6-dimethyl-2-methylsulfanylbenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
    5,6-Dimethyl-2-(methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole化学式
    CAS
    22423-16-1
    化学式
    C15H20N2O4S
    mdl
    ——
    分子量
    324.4
    InChiKey
    NIVGWMZXARPLTJ-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      1.4
    • 重原子数：
      22
    • 可旋转键数：
      3
    • 环数：
      3.0
    • sp3杂化的碳原子比例：
      0.53
    • 拓扑面积：
      113
    • 氢给体数：
      3
    • 氢受体数：
      6

    文献信息

    • Prevention and treatment of inflammation-induced and/or immune-mediated bone loss
      申请人：onepharm Research & Development GmbH
      公开号：EP2036548A1
      公开（公告）日：2009-03-18
      The present invention relates to the use of an 11-β-HSD-type 1 and/or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.
      本发明涉及使用 11-β-HSD 1 型和/或 2 型抑制剂制造药剂，以预防和/或治疗炎症诱导和/或免疫介导的骨和/或软骨损失。
    • 11Beta -Hydroxysteroid Dehydrogenases
      申请人：Wilckens Thomas
      公开号：US20080153791A1
      公开（公告）日：2008-06-26
      The present invention relates to novel 11β-HSD inhibitors as well as to the use of 11 β-HSD inhibitors for the manufacture of pharmaceutical agents for the prevention and/or treatment of metabolic diseases, cancer, cell proliferation, glaucoma, diseases associated with abnormal growth hormone secretion as well as wound healing disorders.
    • PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS
      申请人：WILCKENS Thomas
      公开号：US20110275584A1
      公开（公告）日：2011-11-10
      The present invention relates to the use of an 11-β-HSD-type 1 and/or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.
    查看更多

    同类化合物

    [(2R,3R,4R,5R)-2-(5,6-二氯苯并咪唑-1-基)-4-羟基-5-(羟基甲基)四氢呋喃-3-基]磷酸二氢酯 BENZIMIDAVIR苯并咪唑核苷 5,6-二甲基-1-(5-O-膦酰-alpha-D-呋喃核糖基)-1H-苯并咪唑 5,6-二氯-1-β-D-呋喃核糖基苯并咪唑 2-氯-5,6-二甲基-1-beta-D-呋喃核糖基苯并咪唑 2,5-哌嗪二酮,3-甲基-6-(2-甲基丙基)-,反-(9CI) 1,3-二去氮杂腺苷 (2S,3R,4S,5R)-2-(5,6-二甲基苯并咪唑-1-基)-5-(羟基甲基)四氢呋喃-3,4-二醇 5,6-dichloro-2-<(4-chlorobenzyl)thio>-1-β-D-ribofuranosylbenzimidazole 5,6-dichloro-2-<(4-nitrobenzyl)thio>-1-β-D-ribofuranosylbenzimidazole 9-(1-β-D-arabinofuranosyl)-6-nitro-1,3-dideazapurine 9-(1-β-D-arabinofuranosyl)-1,3-dideazaadenine 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)benzimidazole 1-(2,3-O-isopropylidene-α-D-ribofuranosyl)benzimidazole 2-{3-[3-(4-carbamoylpiperidin-1-yl)propoxy]benzylamino}-1-(β-D-ribofuranosyl)-1H-benzimidazole 5-chloro-1-(5-O-sulfamoyl-β-D-ribofuranosyl)-1H-benzimidazole 2-bromo-5,6-dichloro-5'-O-L-lysyl-1-β-D-ribofuranosylbenzimidazole 2-(sec-Butylamino)-5,6-dichloro-1-(beta-L-ribofuranosyl)-1H-benzimidazole 2,5-dimethyl-1-(β-D-erythropentofuranosyl)-1H-benzimidazole 1-β-D-arabinofuranosylbenzimidazole 5,6-Dichloro-1-(beta-L-ribofuranosyl)-2-((2,2,2-trifluoroethyl)amino)-1H-benzimidazole 2-(3-bromobenzylamino)-1-(β-D-ribofuranosyl)-1H-benzimidazole 5,6-dichlorobenzimidazole riboside-5'-O-triphosphate 1,3-bis(β-D-ribofuranosyl)-2-thio-5,6-dichlorobenzimidazole 5,6-dichloro-2-<<3-(trifluoromethyl)benzyl>thio>-1-β-D-ribofuranosylbenzimidazole 2-chloro-5,6-dinitro-1-(β-D-ribofuranosyl)benzimidazole 2-Morpholino-1-(β-D-ribofuranosyl)-benzimidazol 1H-Benzimidazole, 1-(5-O-(hydroxy(phosphonooxy)phosphinyl)-beta-D-ribofuranosyl)- 1H-Benzimidazole, 1-ribofuranosyl- lin.-Benzo-ATP (2R,3R,4S,5S)-2-(5,6-dichloro-2-sulfanyl-benzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol α-ribazole-3'-phosphate 5,6-Dichloro-2-(methylamino)-1-(beta-L-ribofuranosyl)-1H-benzimidazole 1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-1H-benzimidazole (2R,3R,4S,5R)-2-(5,6-dichloro-2-methyl-benzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (2S,3S,4R,5R)-2-(5,6-Dichloro-2-mercapto-benzoimidazol-1-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol 1-<5'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>-5,6-dichloro-2-mercaptobenzimidazole Benzimidazole, 2-chloro-1-beta-D-ribofuranosyl- 2-(Morpholin-4-yl)-1-pentofuranosyl-1h-benzimidazole 1-Pentofuranosyl-2-(piperidin-1-yl)-1h-benzimidazole 2-Methoxy-1-pentofuranosyl-1h-benzimidazole 2-(Methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole 2-(Benzylsulfanyl)-1-pentofuranosyl-1h-benzimidazole N-Methyl-1-pentofuranosyl-1,3-dihydro-2H-benzimidazol-2-imine 1-Pentofuranosyl-1,3-dihydro-2H-benzimidazol-2-imine 1-Pentofuranosyl-1H-benzimidazol-2-ol n,n-Dimethyl-1-pentofuranosyl-1h-benzimidazol-2-amine 5,6-Dimethyl-1-pentofuranosyl-1,3-dihydro-2H-benzimidazol-2-imine 2-(Benzylsulfanyl)-5,6-dimethyl-1-pentofuranosyl-1h-benzimidazole 5,6-Dimethyl-2-(methylsulfanyl)-1-pentofuranosyl-1h-benzimidazole

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