[(η⁶-C₁₀H₁₄)RuCl(fcdpm)] | 1268492-22-3

• 英文名称: [(η⁶-C₁₀H₁₄)RuCl(fcdpm)]
• 英文别名: [(η⁶-C₁₀H₁₄)RuCl(5-ferrocenyldipyrromethene)]
• CAS: 1268492-22-3
• 化学式: C₂₉H₂₉ClFeN₂Ru
• 分子量: 597.933
• InChiKey: NHEUITGWQDILDF-XYIBNCDISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  硫氰酸铵 、 [(η⁶-C₁₀H₁₄)RuCl(fcdpm)] 以 丙酮 为溶剂， 以74%的产率得到[(η6-cymene)Ru(SCN)(5-ferrocenyldipyrromethane(-H))]
  参考文献：
  名称：

  Heteroleptic half-sandwich Ru(II), Rh(III) and Ir(III) complexes based on 5-ferrocenyldipyrromethene

  摘要：

  The synthesis and characterization of heteroleptic complexes with the formulations [(eta(6)-arene)RuCl(fcdpm)] (eta(6)-arene = C6H6, C10H14) and [(eta(5)-C5Me5)MCl(fcdpm)] (M = Rh, Ir; fcdpm = 5-ferrocenyldipyrromethene) have been reported. All the complexes have been characterized by elemental analyses, IR, H-1 NMR and electronic spectral studies. Structures of [(eta(6)-C6H6)RuCl(fcdpm)] and [(eta(6)-C10H14)RuCl(fcdpm)] have been determined crystallographically. Chelating monoanionic linkage of fcdpm to the respective metal centres has been supported by spectral and structural studies. Further, reactivity of the representative complex [(eta(6)-C10H14) RuCl(fcdpm)] with ammonium thiocyanate (NH4SCN) and triphenylphosphine (PPh3) have been examined. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.09.070
• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 5-ferrocenyldipyrromethane 在 DDQ 、 Et₃N 作用下， 以 甲醇 、 氯仿 、 苯 为溶剂， 以45%的产率得到[(η⁶-C₁₀H₁₄)RuCl(fcdpm)]
  参考文献：
  名称：

  Heteroleptic half-sandwich Ru(II), Rh(III) and Ir(III) complexes based on 5-ferrocenyldipyrromethene

  摘要：

  The synthesis and characterization of heteroleptic complexes with the formulations [(eta(6)-arene)RuCl(fcdpm)] (eta(6)-arene = C6H6, C10H14) and [(eta(5)-C5Me5)MCl(fcdpm)] (M = Rh, Ir; fcdpm = 5-ferrocenyldipyrromethene) have been reported. All the complexes have been characterized by elemental analyses, IR, H-1 NMR and electronic spectral studies. Structures of [(eta(6)-C6H6)RuCl(fcdpm)] and [(eta(6)-C10H14)RuCl(fcdpm)] have been determined crystallographically. Chelating monoanionic linkage of fcdpm to the respective metal centres has been supported by spectral and structural studies. Further, reactivity of the representative complex [(eta(6)-C10H14) RuCl(fcdpm)] with ammonium thiocyanate (NH4SCN) and triphenylphosphine (PPh3) have been examined. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.09.070

文献信息

• Interaction of ferrocene appended Ru(II), Rh(III) and Ir(III) dipyrrinato complexes with DNA/protein, molecular docking and antitumor activity
  作者：Rajendra Prasad Paitandi、Rakesh Kumar Gupta、Roop Shikha Singh、Gunjan Sharma、Biplob Koch、Daya Shankar Pandey

  DOI：10.1016/j.ejmech.2014.06.052

  日期：2014.9

  Efficacy of the ferrocene appended piano-stool dipyrrinato complexes [(η(6)-C6H6)RuCl(fcdpm)] (1), [(η(6)-C10H14)RuCl(fcdpm)] (2), [(η(6)-C12H18)RuCl(fcdpm)] (3) [(η(5)-C5Me5)RhCl(fcdpm)] (4) and [(η(5)-C5Me5)IrCl(fcdpm)] (5) [fcdpm = 5-ferrocenyldipyrromethene] toward anticancer activity have been described. Binding of the complexes with calf thymus DNA (CT-DNA) and BSA (bovine serum albumin) have been thoroughly investigated by UV-Vis and fluorescence spectroscopy. Binding constants for 1-5 (range, 10(4)-10(5) M(-1)) validated their efficient binding with CT-DNA. Molecular docking studies revealed interaction through minor groove of the DNA, on the other hand these also interact through hydrophobic residues of the protein, particularly cavity in the subdomain IIA. In vitro anticancer activity have been scrutinized by MTT assay, acridine orange/ethidium bromide (AO/EtBr) fluorescence staining, and DNA ladder (fragmentation) assay against Dalton's Lymphoma (DL) cells. Present study revealed that rhodium complex (4) is more effective relative to ruthenium (1-3) and iridium (5) complexes.