2-(2,5-Dimethyl-phenoxy)-propionaldehyde | 53552-44-6

• 英文名称: 2-(2,5-Dimethyl-phenoxy)-propionaldehyde
• 英文别名: 2-(2,5-Dimethylphenoxy)propanal
• CAS: 53552-44-6
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: NNXDRNYCUYARFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  一氧化碳 、 2,5-Dimethylphenyl-vinylether 在 铑 氢气 作用下， 生成 2-(2,5-Dimethyl-phenoxy)-propionaldehyde
  参考文献：
  名称：

  FR2213928

  摘要：

  公开号：

文献信息

• Methods of treating various diseases using carnitine conjugates as dual prodrugs
  申请人：Goel Om P.

  公开号：US20080188444A1

  公开（公告）日：2008-08-07

  The present invention discloses uses for treating various diseases with novel dual prodrug compounds of Formula 1, wherein A is selected from the group consisting of a single bond, —O—, or —CH 2 —; m and n vary independently and are an integer from 1 to 15; p and q vary independently from 0 to 1; B is —CR 3 R 4 ; D is selected from the group consisting of —CO 2 R 5 , —OR 6 , —OCOR 7 , —SO 3 R 8 , —SO 2 NH 2 , —OPO(OR 9 )(OR 10 ), —OPO(OR 9 )(NH 2 ), —OPO(OR 9 )—O—PO(OR 10 )(OR 11 ), wherein R 1 to R 4 are independently selected from C 1 -C 6 alkyl; and R 5 to R 11 are independently selected from the group consisting of hydrogen; C 1 -C 6 alkyl; C 3 -C 6 cycloalkyl; C 2 -C 6 alkenyl; C 6 alkynyl; C 5 -C 10 aryl unsubstituted or substituted with C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, carboxyl, C 1 -C 6 acyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 acylamino, C 1 -C 6 alkoxylcarbonyl; C 5 -C 6 arylalkyl unsubstituted or substituted with C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, carboxyl, C 1 -C 6 acyl, C 1 -C 6 hydroxyalkyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 1 -C 6 alkoxylcarbonyl; C 1 -C 6 carboxyalkyl; C 1 -C 6 acylamino; C 1 -C 6 sulfonatoalkyl; C 1 -C 6 sulfamylalkyl; and C 1 -C 6 phosphonatoalkyl. The various terms in Formula 1 are selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1. There compounds are useful for the treatment of various metabolic, cardiovascular and neurological disorders.
• US7345190B2
  申请人：——

  公开号：US7345190B2

  公开（公告）日：2008-03-18