ethyl 4-(bromoacetyl)-1-(2-chlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate | 1260400-14-3

• 英文名称: ethyl 4-(bromoacetyl)-1-(2-chlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate
• 英文别名: ethyl 4-(2-bromoacetyl)-1-(2-chlorophenyl)-5-methylpyrazole-3-carboxylate
• CAS: 1260400-14-3
• 化学式: C₁₅H₁₄BrClN₂O₃
• 分子量: 385.645
• InChiKey: XPPDEXPZYNBFCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,5-二苯基-4H-1,2,4-噻唑-3-硫醇 、 ethyl 4-(bromoacetyl)-1-(2-chlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 3.5h， 以60%的产率得到ethyl 1-(2-chlorophenyl)-4-[2-(4,5-diphenyl-4H-1,2,4-triazol-3-ylsulfanyl)-1-oxoethyl]-5-methyl-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones

  摘要：

  Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.

  DOI：

  10.1134/s1070428010100192
• 作为产物：
  描述：

  ethyl 4-acetyl-1-(2-chlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate 在 硫酸 、 溴 作用下， 以 溶剂黄146 为溶剂， 反应 7.0h， 以81%的产率得到ethyl 4-(bromoacetyl)-1-(2-chlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones

  摘要：

  Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.

  DOI：

  10.1134/s1070428010100192