hydroxymethylbilane synthase | 9074-91-3

• 分子结构分类: 转移酶 - 转移烷基或芳基（甲基除外） - 转移除甲基以外的烷基或芳基（有子类）
• 英文名称: hydroxymethylbilane synthase
• 英文别名: HMB-synthase；porphobilinogen deaminase；pre-uroporphyrinogen synthase；uroporphyrinogen I synthase；uroporphyrinogen I synthetase；uroporphyrinogen synthase；uroporphyrinogen synthetase；porphobilinogen ammonia-lyase (polymerizing)；(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
• CAS: 9074-91-3；9036-47-9

反应信息

• 作为试剂：
  描述：

  5-9氨基甲基)-4-(羧甲基)-1H-吡咯-3-丙酸 在 hydroxymethylbilane synthase 、 uroporphyrinogen synthase 作用下， 生成 尿紫元(III)
  参考文献：
  名称：

  Handling heme: The mechanisms underlying the movement of heme within and between cells

  摘要：

  Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely transported and trafficked from the site of synthesis in the mitochondria or uptake at the cell surface, to hemoproteins in most subcellular compartments. While heme synthesis and degradation are relatively well characterized, little is known about how heme is trafficked and transported throughout the cell. Herein, we review eukaryotic heme transport, trafficking, and mobilization, with a focus on factors that regulate bioavailable heme. We also highlight the role of gasotransmitters and small molecules in heme mobilization and bioavailability, and heme trafficking at the host-pathogen interface.

  DOI：

  10.1016/j.freeradbiomed.2018.08.005