(2-MeO-Ph)3PAuCl | 947510-24-9

• 英文名称: (2-MeO-Ph)3PAuCl
• 英文别名: chloro(tris(2-methoxyphenyl)phosphine)gold(I)；[Au(tris(o-methoxyphenyl)phosphane)Cl]；[AuP(oanis)3Cl]；Au(tris(2-methoxyphenyl)phosphine)Cl
• CAS: 947510-24-9
• 化学式: C₂₁H₂₁AuClO₃P
• 分子量: 584.789
• InChiKey: UJTMPQMEGQUSHG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (2-MeO-Ph)3PAuCl 、 三苯基膦 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 [Au{tris(o-methoxyphenyl)phosphane}{triphenylphosphine}]Cl
  参考文献：
  名称：

  含三（邻甲氧基苯基）磷烷的金（I）配合物的合成、抗癌活性和凋亡诱导

  摘要：

  四种新的磷化金（I）配合物；[Au{( o -MeO-Ph) 3 P}Cl] ( 1 ), [Au{( o -MeO-Ph) 3 P}{(Me-Et-Ph)P}]Cl ( 2 ), [Au {( o -MeO-Ph) 3 P}(Ph 3 P)]Cl ( 3 ) 和 [Au{( o -MeO-Ph) 3 P} 2 ]Cl ( 4 ) (其中o -MeO-Ph) 3 P = 三（o-甲氧基苯基）膦和（Me-Et-Ph）P =甲基乙基苯基膦）被制备并通过元素分析、FTIR和NMR光谱表征。其中一种配合物的结构由 X 射线晶体学确定，表明金 (I) 原子与磷和 Cl 原子线性配位。在体外的复合物的细胞毒性进行了研究针对四种人类肿瘤细胞系; A549、海拉、MDA-MB-231 和 MCF7。在所有情况下，测试的复合物对所选细胞都显示出优异的细胞毒性，IC 50值远低于顺铂。为了知道细胞死亡的可能方式，复合体1进一步评估了对

  DOI：

  10.1016/j.ica.2021.120567
• 作为产物：
  描述：

  四氯金酸水合物 、 三(2-甲氧基苯基)膦 在 二丙硫醚 作用下， 以 乙醇 为溶剂， 反应 1.17h， 以95%的产率得到(2-MeO-Ph)3PAuCl
  参考文献：
  名称：

  Efficient General Procedure To Access a Diversity of Gold(0) Particles and Gold(I) Phosphine Complexes from a Simple HAuCl₄Source. Localization of Homogeneous/Heterogeneous System’s Interface and Field-Emission Scanning Electron Microscopy Study

  摘要：

  Soluble gold precatalysts, aimed for homogeneous catalysis, under certain conditions may form nanoparticles, which dramatically change the mechanism and initiate different chemistry. The present study addresses the question of designing gold catalysts, taking into account possible interconversions and contamination at the homogeneous/heterogeneous system's interface. It was revealed that accurate localization of boundary experimental conditions for formation of molecular gold complexes in solution versus nucleation and growth of gold particles opens new opportunities for well-known gold chemistry. Within the developed concept, a series of practical procedures was created for efficient synthesis of soluble gold complexes with various phosphine ligands (R3P)AuCl (90-99% yield) and for preparation of different types of gold materials. The effect of the ligand on the particles growth in solution has been observed and characterized with high-resolution field-emission scanning electron microscopy (FE-SEM) study. Two unique types of nanostructured gold materials were prepared: hierarchical agglomerates and gold mirror composed of ultrafine smoothly shaped particles.

  DOI：

  10.1021/ja311258e
• 作为试剂：
  描述：

  3-氯苯乙炔 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 (2-MeO-Ph)3PAuCl 、 (S)-2-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-6-(trifluoromethyl)phenol 、 camphor-10-sulfonic acid 、 双三氟甲烷磺酰亚胺银盐 、 三氟化硼乙醚 、 silica gel 、 copper(II) bis(trifluoromethanesulfonate) 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 异丙醇 、 甲苯 为溶剂， 反应 39.67h， 生成 ethyl (S)-3-(4-(3-chlorophenyl)-1,10-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrrol-10-yl)-2-oxopropanoate
  参考文献：
  名称：

  Copper Catalyzed Enantioselective Alkylation of Pyrrole with β,γ-Unsaturated α-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis

  摘要：

  A highly enantioselective Friedel Crafts alkylation of pyrrole to beta,gamma-unsaturated alpha-ketoesters was developed by virtue of a chiral copper complex, affording the alkylated derivatives of pyrrole with good yields and excellent enantioselectivities. Moreover, merging copper catalysis with gold catalysis realized a one-pot construction of the seven-membered ring to give annulated pyrroles with moderate to good yields and high enantiomeric excesses.

  DOI：

  10.1021/acs.orglett.5b01917

文献信息

• Structural studies of two-coordinate complexes of tris(2-methoxylphenyl)phosphine and tris(4-methoxyphenyl)phosphine with gold(I) halides
  作者：Raymond C. Bott、Peter C. Healy、Graham Smith

  DOI：10.1016/j.poly.2007.01.014

  日期：2007.7

  A series of five gold(I) halide complexes with the two isomeric methoxy-substituted triarylphosphines, tris(2-methoxyphenyl)phosphine [P(oaniS)(3)] [AuP(oaniS)(3)X] [for X = Cl, (1); X = Br, (2) and X = I, (3)] and tris(4-methoxyphenyl)phosphine [P(paniS)(3)], [AuP(panis)(3)X] [for X = Br (4) and X = I (5)] have been synthesized and characterized by single crystal X-ray diffraction and solution P-31H-1} NMR spectroscopy. The structure determinations confirm the expected presence of linear two-coordination about the gold centres in all five complexes with bond distance and angle data typical of this type of compound [Au-P, 2.239(2)-2.259(3) angstrom; Au-Cl, 2.294(2) angstrom; AuBr, 2.385(2)-2.402(2) angstrom; Au-I, 2.546(1)-2.554(1) angstrom; P-Au-X; 175.3(1)-180 degrees]. All analogues except the iodo complex 5 crystallize with one complex molecule in the crystallographic asymmetric unit. The bromo and iodo complexes 2 and 3 constitute a trigonal isomorphous set while the bromo complex 4 is also isomorphous with the previously determined chloro complex [AuP(panis)(3)Cl]. The 2-methoxy analogues are stabilized by significant methoxy-O...Au interactions. (C) 2007 Elsevier Ltd. All rights reserved.