1-(3-methoxyphenyl)-1,7-dicarba-closo-dodecaborane | 111426-91-6

• 英文名称: 1-(3-methoxyphenyl)-1,7-dicarba-closo-dodecaborane
• 英文别名: 1-(3-methoxyphenyl)-m-carbaborane
• CAS: 111426-91-6
• 化学式: C₉H₁₈B₁₀O
• 分子量: 250.351
• InChiKey: LXDBAUQJJCVZKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-(3-methoxyphenyl)-1,7-dicarba-closo-dodecaborane 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到1-(3-hydroxyphenyl)-1,7-dicarba-closo-dodecaborane
  参考文献：
  名称：

  Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity

  摘要：

  meta-Carboranylphenoxyacetanilides were synthesized by copper catalyzed coupling reaction of meta-carborane and phenyl iodides. The synthesized compounds were evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter gene assay. Among the compounds synthesized, meta-carborane containing phenoxyanilides 2d and 2h, which have an isobutyl group on meta-carborane, exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity toward HeLa cell-based reporter gene assay with the IC50 values of 0.73 and 0.55 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2015.05.029
• 作为产物：
  描述：

  1,7-dicarba-closo-dodecaborane(12) 、 3-碘苯甲醚 在 正丁基锂 、 copper(l) chloride 作用下， 以 乙二醇二甲醚 、 正己烷 、 吡啶 为溶剂， 反应 50.0h， 以28%的产率得到1-(3-methoxyphenyl)-1,7-dicarba-closo-dodecaborane
  参考文献：
  名称：

  Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity

  摘要：

  meta-Carboranylphenoxyacetanilides were synthesized by copper catalyzed coupling reaction of meta-carborane and phenyl iodides. The synthesized compounds were evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter gene assay. Among the compounds synthesized, meta-carborane containing phenoxyanilides 2d and 2h, which have an isobutyl group on meta-carborane, exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity toward HeLa cell-based reporter gene assay with the IC50 values of 0.73 and 0.55 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2015.05.029

文献信息

• Kovredov, A. I.; Shaugumbekova, Zh. S.; Kazantsev, V. A., Journal of general chemistry of the USSR, 1986, vol. 56, p. 2045 - 2049
  作者：Kovredov, A. I.、Shaugumbekova, Zh. S.、Kazantsev, V. A.、Zakharkin, L. I.

  DOI：——

  日期：——