2-[bis[2-[[(2S)-1-hydroxy-4-methylpentan-2-yl]amino]-2-oxoethyl]amino]-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]acetamide | 1092554-62-5

• 英文名称: 2-[bis[2-[[(2S)-1-hydroxy-4-methylpentan-2-yl]amino]-2-oxoethyl]amino]-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]acetamide
• CAS: 1092554-62-5
• 化学式: C₂₄H₄₈N₄O₆
• 分子量: 488.668
• InChiKey: LMULCJKXNXHHQF-ACRUOGEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  34
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  151
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[bis[2-[[(2S)-1-hydroxy-4-methylpentan-2-yl]amino]-2-oxoethyl]amino]-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]acetamide 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以90%的产率得到N,N',N''-tris[(1S)-(2-TBDMSO-1-iso-butylethyl)]-nitrilotriacetamide
  参考文献：
  名称：

  Synthesis of novel C3 symmetric tris(thiazoline) ligands and their application in the allylic oxidation reaction

  摘要：

  A series of novel C-3 symmetric tris(thiazoline) ligands were synthesized from trimethyl nitrilotriacetate and an enantiomerically pure amino alcohol via an efficient route. Compound 7a showed moderate to good catalytic enantioselectivity for the asymmetric allylic oxidation of cycloalkenes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.08.028
• 作为产物：
  描述：

  nitrilotriacetic acid trimethyl ester 、 L-亮氨醇 以71%的产率得到2-[bis[2-[[(2S)-1-hydroxy-4-methylpentan-2-yl]amino]-2-oxoethyl]amino]-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]acetamide
  参考文献：
  名称：

  Synthesis of novel C3 symmetric tris(thiazoline) ligands and their application in the allylic oxidation reaction

  摘要：

  A series of novel C-3 symmetric tris(thiazoline) ligands were synthesized from trimethyl nitrilotriacetate and an enantiomerically pure amino alcohol via an efficient route. Compound 7a showed moderate to good catalytic enantioselectivity for the asymmetric allylic oxidation of cycloalkenes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.08.028