1-phenyl-1-(4-dimethylaminopropyloxyphenyl)-2-cymantrenyl-1-butene | 439216-44-1

• 英文名称: 1-phenyl-1-(4-dimethylaminopropyloxyphenyl)-2-cymantrenyl-1-butene
• CAS: 439216-44-1；439216-42-9
• 化学式: C₂₉H₃₀MnNO₄
• 分子量: 511.499
• InChiKey: NKESYUHUFXNONJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  盐酸 、 三氯一茂钛 、 1-phenyl-1-(4-dimethylaminopropyloxyphenyl)-2-cymantrenyl-1-butene 在 C₄H₉Li 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以57%的产率得到
  参考文献：
  名称：

  The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

  摘要：

  The synthesis of 4'. a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4' is prepared by a McMurry coupling followed by a ligand exchange. Compound 4' reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(01)01271-2
• 作为产物：
  描述：

  (Propionylcyclopentadienyl)tricarbonylmanganese 、 4-dimethylaminopropyloxy benzophenone 在 TiCl₄ 、 Zn 作用下， 以 四氢呋喃 为溶剂， 以54%的产率得到1-phenyl-1-(4-dimethylaminopropyloxyphenyl)-2-cymantrenyl-1-butene
  参考文献：
  名称：

  The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

  摘要：

  The synthesis of 4'. a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4' is prepared by a McMurry coupling followed by a ligand exchange. Compound 4' reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(01)01271-2